AI Article Synopsis
- ADP-dependent glucokinase (ADPGK) uses ADP to produce glucose-6-phosphate, differing from the more common ATP-dependent hexokinases.
- Although ADPGK was first identified in archaea and plays a role in glycolysis, its exact functions in eukaryotic organisms remain uncertain, needing more research.
- This paper reviews ADPGK's origins, biological roles, and potential clinical applications, providing insights for diagnosing and treating metabolic diseases, neurological issues, and tumors, while proposing new drug development strategies.
Article Abstract
ADP-dependent glucokinase (ADPGK) produces glucose-6-phosphate with adenosine diphosphate (ADP) as the phosphate group donor, in contrast to ATP-dependent hexokinases (HKs). Originally found in archaea, ADPGK is involved in glycolysis. However, its biological function in most eukaryotic organisms is still unclear, and the molecular mechanism of action requires further investigation. This paper provides a concise overview of ADPGK's origin, biological function and clinical application. It aims to furnish scientific information for the diagnosis and treatment of human metabolic diseases, neurological disorders, and malignant tumours, and to suggest new strategies for the development of targeted drugs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10999526 | PMC |
| http://dx.doi.org/10.3389/fonc.2024.1358904 | DOI Listing |
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