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| http://dx.doi.org/10.1093/ehjopen/oeae022 | DOI Listing |
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Comparison of two aspirin doses for the prophylaxis of pre-eclampsia in twin pregnancy: a multicentre retrospective study with propensity score matching.
Am J Obstet Gynecol
January 2025
Department of Obstetrics and Gynecology, University Hospital Brugmann, Université Libre de Bruxelles, Brussels, Belgium. Electronic address:
Background: Aspirin has proved its efficacy in reducing the rate of preeclampsia in singleton pregnancy, however, there is discrepancy about the efficient dosage that should be used. While some societies recommend daily 75-81mg, others recommend higher dosage (160mg). This discrepancy is due to the lack of randomized controlled studies that compare these two dosages.
View Article and Find Full Text PDFEffect of prior use of statins on endovascular thrombectomy outcomes in acute ischemic stroke.
Clin Neurol Neurosurg
January 2025
Department of Neurology, Milton S. Hershey Medical Center, Penn State University College of Medicine, Hershey, PA, USA. Electronic address:
Introduction: Acute large vessel occlusions (LVOs) account for up to one-third of acute ischemic strokes (AIS) and are associated with high mortality and severe functional deficits. Animal model research suggests that statins may have a protective effect on vessel wall injury during endovascular thrombectomy (EVT). We conducted a retrospective observational study to assess the impact of statin use on clinical outcomes post-EVT in AIS patients with LVOs.
View Article and Find Full Text PDFThe effect of transcutaneous auricular vagus nerve stimulation on cardiovascular function in subarachnoid hemorrhage patients: A randomized trial.
Elife
January 2025
Department of Neurosurgery, Washington University School of Medicine, Springfield, United States.
Background: Subarachnoid hemorrhage (SAH) is characterized by intense central inflammation, leading to substantial post-hemorrhagic complications such as vasospasm and delayed cerebral ischemia. Given the anti-inflammatory effect of transcutaneous auricular vagus nerve stimulation (taVNS) and its ability to promote brain plasticity, taVNS has emerged as a promising therapeutic option for SAH patients. However, the effects of taVNS on cardiovascular dynamics in critically ill patients, like those with SAH, have not yet been investigated.
View Article and Find Full Text PDFBackground: Cerebral microbleeds (CMBs) hold significant clinical relevance, linked to elevated risks of hemorrhages, cognitive decline, and mortality. Notably, with the recent advancement in Alzheimer's treatments, the number of CMBs serves as a crucial safety indicators to assess the risk and occurrence of amyloid-related imaging abnormalities. However, the commonly utilized manual detection process is time-consuming and labor-intensive, prompting the development of various automated detection models.
View Article and Find Full Text PDFBackground: As lecanemab becomes available to people living with dementia, there is a pressing need to understand how they weigh the potential benefits against costs. This study investigates how older adults perceive lecanemab's risks and benefits and their approach to treatment decisions.
Methods: Semi-structured interviews of older adults undergoing evaluation in Neurology clinics for lecanemab eligibility at two academic medical centers.
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