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Shattering the Amyloid Illusion: The Microbial Enigma of Alzheimer's Disease Pathogenesis-From Gut Microbiota and Viruses to Brain Biofilms.
Microorganisms
January 2025
Translational Neuropharmacology Laboratory, Department of Psychology, University of Cyprus, 75 Kallipoleos Avenue, 1678 Nicosia, Cyprus.
For decades, Alzheimer's Disease (AD) research has focused on the amyloid cascade hypothesis, which identifies amyloid-beta (Aβ) as the primary driver of the disease. However, the consistent failure of Aβ-targeted therapies to demonstrate efficacy, coupled with significant safety concerns, underscores the need to rethink our approach to AD treatment. Emerging evidence points to microbial infections as environmental factors in AD pathoetiology.
View Article and Find Full Text PDF[The iatrogenic risk of institutional care in the management of patients with anorexia nervosa].
Soins
January 2025
Institut des sciences humaines en médecine, centre hospitalier universitaire vaudois, Université de Lausanne, avenue de Provence 82, 1007 Lausanne, Suisse; Laboratoire de psychologie clinique, psychopathologie, psychanalyse, École doctorale 261, Université Paris Cité, 71 avenue Édouard-Vaillant, 92100 Boulogne-Billancourt, France; Psychiatrie du développement et trajectoires, Inserm U1018, CESP, Hôpital Cochin, Maison de Solenn, 97 boulevard de Port-Royal, 75014 Paris, France. Electronic address:
This article explores the potential iatrogenic impact of institutional care on patients suffering from anorexia nervosa, based on a perspective drawn from the human and social sciences. In particular, it highlights the social mechanisms - such as the collision of intentions, pathological emulation, stigmatization and identity dedifferentiation - that can aggravate pathology in the hospital setting. Four recommendations are put forward for rethinking care, favoring a more holistic and less iatrogenic approach.
View Article and Find Full Text PDFContinuing Revisions: Reconsidering Freud's Biography and Rethinking Our Thinking.
Psychoanal Rev
December 2024
P.O. Box 256, 22 Kimmel Lane, Jamesport, NY 11947, E-mail:
This reflection follows the work of a "Freud basher," Frederick Crews, elucidating some of Sigmund Freud's limitations and errors. It argues that a flawed Freud is preferable to the myth of a godlike genius and recommends ways in which to ground the future of psychoanalytic thinking.
View Article and Find Full Text PDFOccasioned by the publication of , the text represents exchanges held in the summer of 2024 at the invitation of . It addresses the genesis and the history of the project, and its impact on psychoanalytic rethinking, formation, and practice. While exploring the potential and the limits of revisioning, it also raises questions about the nature of transmission of psychoanalytic knowledge and about the field's relation to the state of its own standards in the age of Anthropocene.
View Article and Find Full Text PDFStill rethinking the J-shaped curve: A commentary on Kember et al., 2024.
Alcohol Clin Exp Res (Hoboken)
December 2024
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA.
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