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Omics approaches: Role in acute myeloid leukemia biomarker discovery and therapy.
Cancer Genet
January 2025
PhD of Hematology, Assistant Professor, Department of Medical Laboratory Sciences, School of Paramedical Sciences, Hamadan University of Medical Sciences, Hamadan, Iran. Electronic address:
Acute myeloid leukemia (AML) is the most common acute leukemia in adults and has the highest fatality rate. Patients aged 65 and above exhibit the poorest prognosis, with a mere 30 % survival rate within one year. One important issue in optimizing outcomes for AML patients is their limited ability to predict responses to specific therapies, response duration, and likelihood of relapse.
View Article and Find Full Text PDFNovel Leech Antimicrobial Peptides, Hirunipins: Real-Time 3D Monitoring of Antimicrobial and Antibiofilm Mechanisms Using Optical Diffraction Tomography.
Adv Sci (Weinh)
January 2025
Department of Biological Sciences and Biotechnology, College of Natural Sciences, Chungbuk National University, Cheongju, Chungbuk, 28644, Republic of Korea.
Antimicrobial peptides (AMPs) are promising agents for treating antibiotic-resistant bacterial infections. Although discovering novel AMPs is crucial for combating multidrug-resistant bacteria and biofilm-related infections, their clinical potential relies on precise, real-time evaluation of efficacy, toxicity, and mechanisms. Optical diffraction tomography (ODT), a label-free imaging technology, enables real-time visualization of bacterial morphological changes, membrane damage, and biofilm formation over time.
View Article and Find Full Text PDFDiscovery of Knowledge in Practice.
Am J Occup Ther
January 2025
Nicole Quint, PhD, DrOT, OTR/L, is Professor and Program Director, Dual Degree DrOT/PhD and DrOT Programs, Nova Southeastern University, Ft. Lauderdale, FL;
Given the number of occupational therapy doctorate (OTD) programs and graduates with professional doctoral degrees, the concept of practice scholarship is increasingly important. The scholarly work of occupational therapy practitioners guided by a research model is appropriate for those who have trained as researchers or OTD students and practitioners receiving mentorship from occupational therapy research scientists. A research model of scholarship may not fit the scholarly work of most occupational therapy practitioners with an OTD.
View Article and Find Full Text PDFFungal Osteomyelitis of a Diabetic Foot Infection Caused by Trichosporon asahii: A Case Report.
Adv Skin Wound Care
January 2025
At Baylor College of Medicine, Houston, Texas, United States, Livia Frost, BS, is Medical Student, School of Medicine; Ya Xu, MD, PhD, is Assistant Professor, Department of Pathology & Immunology; and Yuriko Fukuta, MD, PhD, CWSP, is Assistant Professor, Department of Medicine, Section of Infectious Diseases.
Diabetic foot bacterial osteomyelitis is a serious infection that can lead to major amputations. However, fungal osteomyelitis in a diabetic foot ulcer is uncommon and has been underrecognized. It typically occurs in patients with underlying immunocompromised status and is associated with poor outcomes.
View Article and Find Full Text PDFTreatment of 50 Acute and Chronic Wounds of Multiple Etiologies: A Case Series Looking at Outcomes and Utility of an Extended-Wear Transforming Powder Dressing.
Adv Skin Wound Care
January 2025
In the Department of Surgery, NYU Long Island School of Medicine, Mineola, New York, Sawyer Cimaroli, MD, is Surgical Resident; Danilo Lozada, MS, is Medical Student; and James Daniels, MD, is Surgical Resident. Brian Gillette, PhD, is Research Scientist, Department of Foundation of Medicine, NYU Long Island School of Medicine and Department of Surgery, NYU Langone Hospital Long Island. Scott Gorenstein, MD, is Clinical Assistant Professor, Department of Surgery, NYU Long Island School of Medicine.
Increasing healthcare costs, limited healthcare resources, an aging population, and lifestyle-related diseases make wound management a growing clinical, social, and economic burden. This case series investigated the use of a novel, biocompatible, polymer-based transforming powder dressing (TPD) that transforms in situ to a shape-retentive wound matrix upon hydration for treating wounds of various etiologies.In this institutional review board-approved single-center retrospective case series, the researchers evaluated various acute and chronic wounds treated with TPD over a period of 2 years.
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