AI Article Synopsis
- Amyloid fibril formation occurs when certain proteins and peptides exceed their solubility, leading to a precipitation process similar to crystallization.
- Research using the HANABI inducer has shown that serum albumin inhibits amyloid fibril formation in dialysis-related amyloidosis.
- Understanding the factors that promote or prevent this fibril formation could help in developing early diagnostic tools and preventive strategies for amyloidosis.
Article Abstract
Amyloid fibril formation is a general property of proteins and peptides. It is a physicochemical phenomenon similar to crystallization, in which amyloid precursor proteins exceeding solubility precipitate through the breakdown of supersaturation. Using the ultrasonication-forced amyloid fibril inducer HANABI, we have discovered that serum albumin acts as an inhibitor in dialysis-related amyloidosis. Exploring the factors that induce or inhibit amyloid fibril formation using HANABI can lead to the development of early diagnosis and prevention methods for amyloidosis.
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| http://dx.doi.org/10.11477/mf.1416202616 | DOI Listing |
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