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Antisense mediated blockade of Dickkopf 1 attenuates tumor survival, metastases and bone damage in experimental osteosarcoma.
Sci Rep
January 2025
Department of Medical Physiology, Texas A&M College of Medicine, Bryan, TX, 77807, USA.
Osteosarcoma (OS) is the most common primary bone malignancy. The canonical Wnt inhibitor Dickkopf-1 (Dkk-1) has been implicated in bone destruction, tumor survival and metastases during OS. We examined the role of Dkk-1 in OS disease progression and explored strategies for targeting its activity.
View Article and Find Full Text PDFInhibitors of the Wnt pathway in osteoporosis: A review of mechanisms of action and potential as therapeutic targets.
Biomol Biomed
November 2024
School of Tradional Chinese and Werstern Medicine, Gansu University of Chinese Medicine, Lanzhou, China.
The Wnt signaling pathway is one of the most important and critical signaling pathways for maintaining cellular functions, such as cell proliferation and differentiation. Increasing evidence substantiates that the Wnt signaling pathway also plays a significant role in the regulation of bone formation in osteoporosis. Accordingly, inhibitors of this pathway, such as sclerostin, Dickkopf-1 (DKK1), WNT inhibitory factor 1 (WIF1), and secreted frizzled-related proteins (SFRPs), have a negative regulatory role in bone formation and may serve as effective therapeutic targets for osteoporosis.
View Article and Find Full Text PDFNovel DNA Aptamers to Dickkopf-1 Protein and Their Application in Colorimetric Sandwich Assays for Target Detection in Patients with Axial Spondyloarthritis.
Int J Mol Sci
November 2024
Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, Lavrentiev Ave. 8, Novosibirsk 630090, Russia.
Chronic immunoinflammatory rheumatic diseases, such as axial spondyloarthritis (AxSpA), are accompanied by a dysregulation of bone remodeling. Among potential biomarkers of bone metabolism, the Wnt pathway antagonist, Dickkopf-1 (DKK-1), is of particular interest because of its potential to reflect a shift towards joint ossification or osteoporosis, but its diagnostic value needs validation. There is still a lack of stable and efficient methods of measuring serum DKK-1 levels suitable for longitude studies.
View Article and Find Full Text PDFAdeno-Associated Virus-Mediated Gene Transduction Reduces Silica-Induced Oxidative Stress and Silicosis in Mouse Lung.
Antioxid Redox Signal
November 2024
Department of Anatomy and Cell Biology, University of Iowa, Iowa City, Iowa, USA.
Silicosis is a lung disease caused by inhalation of silica particles. Both silica-induced oxidative stress and aberrant activation of the Wnt/β-catenin signaling pathway are potential targets in the treatment of pulmonary fibrosis. Dickkopf-1 (Dkk1), an inhibitor of the Wnt/β-catenin signaling pathway, plays regulatory roles in cell fate determination and immune responses.
View Article and Find Full Text PDFCharacterization of cell states in biliary tract cancers identifies mechanisms of therapeutic resistance in a phase II trial of DKN-01/nivolumab.
medRxiv
October 2024
Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Article Synopsis
- Biliary tract cancers show strong resistance to treatments, and effective therapies for these advanced cases are currently limited.
- A clinical trial combined DKN-01 and nivolumab to see if they could help patients with advanced biliary tract cancer, but no positive results were found.
- Researchers analyzed tissue samples to identify different cell types that contribute to the cancer's resistance, discovering new immune and malignant cell states that could inform future treatment strategies.
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