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Quantification and interpretation of nitric oxide-dependent cutaneous vasodilation during local heating.
J Appl Physiol (1985)
November 2024
Department of Health and Human Physiology, The University of Iowa, Iowa City, Iowa, United States.
Human cutaneous microdialysis approaches for assessing nitric oxide (NO)-dependent blood flow include local heating (LH) of the skin until a plateau is reached, followed by infusion of a NO synthase inhibitor such as -nitro-l-arginine methyl ester (l-NAME); however, varied methods of quantifying and expressing NO-dependent vasodilation can obfuscate data interpretation and reproducibility. We retrospectively assessed NO-dependent vasodilation during LH to 39°C or 42°C, calculated as the ) absolute contribution of the NO-dependent component (along with baseline and the non-NO-dependent component) to the total cutaneous vascular conductance (CVC) response to LH, normalized to maximal CVC (%CVC); ) difference in %CVC (Δ%CVC) between the LH plateau and post-NO synthase inhibition (l-NAME plateau; Δ%CVC = LH plateau - l-NAME plateau); ) percentage of the LH plateau attributable to Δ%CVC (%plateau = Δ%CVC/LH plateau × 100); and ) %plateau when correcting for baseline. The LH plateaus during 39°C and 42°C were 48 ± 17%CVC (9 ± 5% baseline; 2 ± 4% non-NO dependent; 36 ± 15% NO dependent) and 88 ± 10%CVC (15 ± 8% baseline; 9 ± 10% non-NO dependent; 64 ± 13% NO dependent), respectively.
View Article and Find Full Text PDFA systematic review and meta-analysis of bovine tuberculosis occurrence and burden in Bangladesh, 1970-2023.
Epidemiol Infect
October 2024
Department of Medicine, Bangladesh Agricultural University, Mymensingh, Bangladesh.
We aimed to estimate the overall apparent prevalence, true prevalence, and the spatial, temporal, and test-specific burden of bovine tuberculosis in Bangladesh. PubMed, Web of Science, Scopus, Google Scholar, and BanglaJOL were searched for bovine tuberculosis publications in Bangladesh from 1 January 1970 to 23 June 2023. Of 142 articles screened, systematic review and meta-analysis were performed on 22 (15.
View Article and Find Full Text PDFCorrection of Infraorbital Dark Circles Using Autologous Adipose-Derived Collagen Filler: A Novel Regenerative Option.
Aesthetic Plast Surg
November 2024
Department of Plastic and Cosmetic Surgery, Nanfang Hospital, Southern Medical University, Guangdong, China.
Article Synopsis
- The study investigates a new technique for treating infraorbital dark circles using adipose-derived extracellular matrix concentrate (ACF) through intradermal injections in female patients aged 20-38.
- Results from 92 participants showed that 86% were satisfied with the treatment, claiming improvements in the appearance of their under-eye skin.
- The technique is seen as effective, with over 97% of patients rated as having improved conditions, and no complications observed during the follow-up period.
An Evaluation of Skin and Immunological Responses after Using a Novel Cross-Linked Porcine-Based Dermal Injectable Collagen with Lidocaine for Nasolabial Fold Correction.
J Clin Med
September 2024
Division of Plastic Surgery, Tri-Service General Hospital, Taipei 100, Taiwan.
Article Synopsis
- A study compared the hypersensitivity reactions of a new dermal filler (test filler) made with a novel cross-linking technology to a traditional filler (control filler) for correcting nasolabial folds.
- Participants (n = 279) underwent a screening allergy test with intradermal injections, where the test filler showed no allergic reactions (0%) while the control filler had a small percentage (1.5%).
- Overall, the test filler had fewer hypersensitivity reactions, no serious adverse events related to its use, and most side effects were common and resolved within a year, supporting its safe application without skin testing beforehand.
Corrigendum: 1270 nm near-infrared light as a novel vaccine adjuvant acts on mitochondrial photoreception in intradermal vaccines.
Front Immunol
June 2024
Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan.
[This corrects the article DOI: 10.3389/fimmu.2022.
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