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PNPLA3 in Alcohol-Related Liver Disease.
Liver Int
January 2025
Department of Gastroenterology, Hepatopancreatology and Digestive Oncology, Hôpital Universitaire de Bruxelles, Université Libre de Bruxelles, Brussels, Belgium.
The discovery of PNPLA3 as a genetic risk factor for liver disease has transformed our understanding of the pathogenesis of alcohol-related liver disease (ALD). The recent reclassification of fatty liver disease as steatotic liver disease (SLD), introducing metabolic dysfunction and alcohol-related liver disease (MetALD), has highlighted how genetic and environmental factors synergistically drive liver damage. The PNPLA3 rs738409 variant stands as a paradigmatic example of gene-environment interaction, where its effect on liver disease is dramatically amplified by alcohol consumption, obesity and type 2 diabetes.
View Article and Find Full Text PDFLarge language models as a diagnostic support tool in neuropathology.
J Pathol Clin Res
November 2024
Else Kröner Fresenius Center for Digital Health, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD Dresden University of Technology, Dresden, Germany.
The WHO guidelines for classifying central nervous system (CNS) tumours are changing considerably with each release. The classification of CNS tumours is uniquely complex among most other solid tumours as it incorporates not just morphology, but also genetic and epigenetic features. Keeping current with these changes across medical fields can be challenging, even for clinical specialists.
View Article and Find Full Text PDFType II Genial Tubercle Fracture.
Anesthesiology
August 2024
Department of Anesthesiology, Nanchong Central Hospital, Second Clinical Medical Institution, North Sichuan Medical College, Nanchong, China.
Changes in physical properties of universal composites and CAD/CAM materials after bleaching and antioxidant applications: Scanning electron microscope and atomic force microscope evaluation.
Microsc Res Tech
May 2024
Faculty of Dentistry, Restorative Dentistry, Selcuk University, Konya, Turkey.
To evaluate the effects of vital bleaching agents and the subsequent application of ascorbic acid (AA) to universal composites and resin-based CAD/CAM blocks on the physical properties of materials. In the study; G-enial A'chord (GCA), Filtek Ultimate (FU), Clearfil Majesty (CM) composites, and LAVA Ultimate (LU), Cerasmart (GCC) CAD/CAM blocks were used. The materials were divided into two subgroups based on the applied bleaching type (n = 30/group): office bleaching (OB) and home bleaching (HB).
View Article and Find Full Text PDFDeep learning-based subtyping of gastric cancer histology predicts clinical outcome: a multi-institutional retrospective study.
Gastric Cancer
September 2023
Else Kroener Fresenius Center for Digital Health, Technical University Dresden, Dresden, Germany.
Introduction: The Laurén classification is widely used for Gastric Cancer (GC) histology subtyping. However, this classification is prone to interobserver variability and its prognostic value remains controversial. Deep Learning (DL)-based assessment of hematoxylin and eosin (H&E) stained slides is a potentially useful tool to provide an additional layer of clinically relevant information, but has not been systematically assessed in GC.
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