AI Article Synopsis
- The study aimed to compare three diagnostic methods for heart failure with preserved ejection fraction (HFpEF): diastolic stress echocardiography (DSE), the H₂FPEF score, and the HFA-PEFF algorithm.
- It involved 80 patients suspected of having HFpEF, where various scores and biomarker concentrations were measured prior to DSE.
- Results indicated that the HFA-PEFF algorithm identified more cases of HFpEF than DSE, while both of the scoring methods had limited ability to accurately predict positive DSE results, highlighting the need for improved diagnostic tools.
Article Abstract
Background: The aim of our study was to compare 3 diagnostic pathways: diastolic stress echocardiography (DSE) based on the ASE/EACVI 2016 guidelines, the 2018 H₂FPEF score, and the 2019 HFA-PEFF algorithm, in patients suspected of heart failure with preserved ejection fraction (HFpEF).
Methods: The study group included 80 consecutive patients with a clinical suspicion of HFpEF. The H₂FPEF and HFA-PEFF scores and serum NT-proBNP concentrations were assessed in all the patients before they were sent for DSE.
Results: The DSE-based pathway confirmed HFpEF in 17 (21%) patients, the HFA-PEFF algorithm in 43 (54%), and H₂FPEF scoring in 4 (5%) patients. The ROC analysis showed that HFA-PEFF score > 5 predicts a DSE-positive test with a sensitivity of 70.5% and a specificity of 65%, (AUC = 0.711, p = 0.002) with a negative predictive value of 89.1% and positive predictive value of 35.3%. The H₂FPEF score > 3 had a negative predictive value of 90%, a positive predictive value of 29.8%, and predicted positive DSE result with a sensitivity of 82.3% but rather poor specificity of 47.6% (AUC = 0.692, p = 0.004). Both H₂FPEF and HFA-PEFF showed similar predictive values (AUC) in the prediction of positive DSE test (p = ns).
Conclusions: The HFA-PEFF score overestimated the rate of HFpEF in comparison to DSE and the H₂FPEF score. The H₂FPEF and HFA-PEFF scores showed only modest predictive values of the positive DSE and had a diagnostic power to rule out the HFpEF.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11544415 | PMC |
| http://dx.doi.org/10.5603/cj.95191 | DOI Listing |
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