Discovery of olimycin E from sp. 11695.

A new natural product olimycin E (), together with two known compounds of divergolide R () and olimycin B (), were obtained from the marine-derived 11695. The structures of were established on the basis of HRESIMS as well as 1D and 2D NMR datasets. The absolute configuration of is identified as 4 R, 6S, 7S, 10 R by comparison the experiment ECD with that of the theoretical ECD. Antibacterial results showed that compound have antibacterial activities against and MRSA with the MIC values of 32 μg/mL, respectively.