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| http://dx.doi.org/10.1002/mdc3.14037 | DOI Listing |
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Reply to: Partially Levodopa-Responsive Parkinsonism in a Carrier of a Novel Pathogenic CLTC Variant.
Mov Disord Clin Pract
June 2024
Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy.
Partially Levodopa-Responsive Parkinsonism in a Carrier of a Novel Pathogenic CLTC Variant.
Mov Disord Clin Pract
June 2024
Institute of Systems Motor Science, CBBM, University of Lübeck, Lübeck, Germany.
Force Control Issues in Upper and Lower Limbs in Parkinson's Disease and Freezing of Gait.
IEEE Trans Neural Syst Rehabil Eng
February 2024
Article Synopsis
- Parkinson's Disease (PD) leads to force control issues in both upper and lower limbs, with about 50% of advanced patients experiencing freezing of gait (FOG), which is tied to these deficits.
- Limited research has focused on how upper-limb force control is affected in PD patients with partially levodopa-responsive FOG (PLR-FOG) compared to those without FOG.
- A study using a haptics-enabled robot revealed significant force control deficits in both limbs of patients with PLR-FOG, although some ability to adjust force in response to resistance remained intact.
Parkin and PINK1 parkinsonism may represent nigral mitochondrial cytopathies distinct from Lewy body Parkinson's disease.
Parkinsonism Relat Disord
December 2009
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Recent authors have concluded that Parkinson's disease (PD) is too heterogeneous to still be considered a single discrete disorder. They advise broadening the concept of PD to include genetic parkinsonisms, and discard Lewy pathology as the confirmatory biomarker. However, PD seen in the clinic is more homogeneous than often recognized if viewed from a long-term perspective.
View Article and Find Full Text PDFEffect of subthalamic nucleus deep brain stimulation on axial motor control and protective arm responses in Parkinson's disease.
Neuroscience
December 2008
Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Stereotactic surgical interventions for Parkinson's disease (PD) can considerably improve appendicular motor signs, but their effect on axial motor signs--especially balance control under optimal drug therapy--remains unclear. Here, we investigated the effect of bilateral subthalamic nucleus (STN) stimulation on levodopa-resistant axial and appendicular postural impairment in PD. Fourteen patients (11 with young-onset PD) and 18 age-matched controls were included.
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