AI Article Synopsis
- - A 70-year-old man experienced symptoms including a distorted taste, chronic diarrhea, and significant weight loss over six months, leading him to seek medical attention.
- - Medical examinations revealed abnormal growths in his stomach and colon, with biopsies showing hamartomatous polyps and signs of inflammation in normal-appearing tissue.
- - After ruling out other hereditary conditions through genetic testing, he was diagnosed with Cronkhite-Canada syndrome and started treatment with Adalimumab after an initial lack of response to prednisone, resulting in clinical improvement.
Article Abstract
A 70-year-old man presented to the clinic with a 6-month history of dysgeusia, followed by chronic, non-bloody diarrhea and 45 lb unintentional weight loss. Esophagogastroduodenoscopy discovered confluent nodularity in the gastric antrum and examined duodenum, but a normal esophagus. Colonoscopy uncovered patches of polypoid nodular mucosa throughout the entire colon. Biopsies of the nodular mucosa were consistent with hamartomatous polyps while biopsies of the intervening, normal-appearing mucosa demonstrated edema with crypt architectural distortion. Other hereditary polyposis syndromes were excluded with genetic testing, confirming a diagnosis of Cronkhite-Canada syndrome. Adalimumab therapy was initiated with clinical improvement after nonresponse to prednisone.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10997232 | PMC |
| http://dx.doi.org/10.14309/crj.0000000000001331 | DOI Listing |
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