AI Article Synopsis
- - This study investigated the impact of chronic hepatitis B (CHB) on health-related quality of life (HRQoL) across five stages in Thai patients, highlighting differences in health state utilities (HSU) and EuroQol-visual analogue scale (EQ-VAS) scores.
- - Data was collected from 422 patients at a super-tertiary care center, with findings showing that HRQoL decreased significantly as the disease progressed, especially in patients with advanced-/terminal-stage hepatocellular carcinoma (HCC).
- - A strong correlation between HSU and EQ-VAS scores was found, indicating that as patients moved to more severe stages, their quality of life and overall health perceptions declined markedly, with the most affected
Article Abstract
Background: Chronic hepatitis B (CHB) significantly impacts the health-related quality of life (HRQoL), but remains underexplored in the Thai population. Health state utilities (HSU) are indicators reflecting HRQoL which serve as fundamental inputs for economic evaluation analyses. This study aimed at assessing differences in HRQoL across five CHB stages in Thai patients, including non-cirrhotic CHB, compensated cirrhosis, decompensated cirrhosis, early-/intermediate-stage hepatocellular carcinoma (HCC) and advanced-/terminal-stage HCC.
Methods: We conducted a cross-sectional study to collect HRQoL data from patients with CHB at five stages. The study included patients with CHB who were followed up at a super-tertiary care centre between March 2021 and February 2022. The participants completed the EQ-5D-5L questionnaire and provided demographic data. Disease stage and relevant data were obtained from medical records. HSU and Euroqol-visual analogue scale (EQ-VAS) scores, calculated using Thai-specific conversion coefficients, were assessed.
Results: Among 422 patients, 236 did not have cirrhosis, 92 had compensated cirrhosis, 13 had decompensated cirrhosis, 55 had early-/intermediate-stage HCC, and 26 had advanced-/terminal-stage HCC. The HSU scores for non-cirrhotic, compensated cirrhosis, decompensated cirrhosis, early-/intermediate-stage HCC and advanced-/terminal-stage HCC were 0.95 ± 0.08, 0.89 ± 0.16, 0.79 ± 0.19, 0.89 ± 0.12 and 0.52 ± 0.39, respectively. Similarly, the EQ-VAS scores for various CHB stages were 83.56 ± 12.90, 80.48 ± 13.03, 68.76 ± 17.40, 79.00 ± 14.38 and 62.92 ± 20.62, respectively. A significant correlation (=0.469, <0.001) was observed between the HSU and EQ-VAS scores. The disease progression led to a notable HSU decline, particularly in the advanced-/terminal-stage HCC group (regression coefficient: -0.436, <0.001). The EQ-VAS scores indicated reduced quality of life in advanced liver disease.
Conclusions: Later CHB stages compromise the HRQoL. Decompensated cirrhosis and advanced-/terminal-stage HCC profoundly affect physical health and quality of life, whereas patients with compensated cirrhosis and early-/intermediate-stage HCC report better HRQoL.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10997410 | PMC |
| http://dx.doi.org/10.1093/gastro/goae015 | DOI Listing |
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