Cough is a common and commonly ignored symptom of lung disease. Cough is often perceived as difficult to quantify, frequently self-limiting, and non-specific. However, cough has a central role in the clinical detection of many lung diseases including tuberculosis (TB), which remains the leading infectious disease killer worldwide. TB screening currently relies on self-reported cough which fails to meet the World Health Organization (WHO) accuracy targets for a TB triage test. Artificial intelligence (AI) models based on cough sound have been developed for several respiratory conditions, with limited work being done in TB. To support the development of an accurate, point-of-care cough-based triage tool for TB, we have compiled a large multi-country database of cough sounds from individuals being evaluated for TB. The dataset includes more than 700,000 cough sounds from 2,143 individuals with detailed demographic, clinical and microbiologic diagnostic information. We aim to empower researchers in the development of cough sound analysis models to improve TB diagnosis, where innovative approaches are critically needed to end this long-standing pandemic.
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http://dx.doi.org/10.1101/2024.03.27.24304980 | DOI Listing |
J Cardiothorac Surg
December 2024
Chirurgie Thoracique et Vasculaire, Assistance Publique-Hôpitaux de Paris, Hôpitaux Universitaires Paris Seine-Saint-Denis, Hôpital Avicenne, Université Sorbonne Paris Nord, Bobigny, France.
Background: A 51-year-old woman was referred to our department due to chronic dry cough lasting six years without an etiological diagnosis. The patient suffered from chronic deterioration in her quality of life due to a persistent cough that sounded like a barking seal.
Case Presentation: A severe form of malacia involving the inferior third of trachea and the main bronchi was diagnosed.
PLoS One
December 2024
Institute of Physiology, Lisbon School of Medicine, University of Lisbon, Lisbon, Portugal.
Objectives: Cough dysfunction is a feature of patients with amyotrophic lateral sclerosis (ALS). The cough sounds carry information about the respiratory system and bulbar involvement. Our goal was to explore the association between cough sound characteristics and the respiratory and bulbar functions in ALS.
View Article and Find Full Text PDFTierarztl Prax Ausg K Kleintiere Heimtiere
December 2024
Kleintierklinik, Ludwig-Maximilians-Universität München.
Two domestic cats (Abyssinian and Carthusian) presented with chronic respiratory signs including cough, respiratory sounds, and polypnea. One of the cats also showed intermittent fever. Thoracic radiographs demonstrated severe changes with predominantly micronodular interstitial lung patterns, some with mineralized areas.
View Article and Find Full Text PDFJ Family Med Prim Care
October 2024
Paediatric Emergency Medicine Unit, Department of Paediatrics, Christian Medical College, Vellore, Tamil Nadu, India.
Background: Definite history is not always present in children with foreign body aspiration (FBA), hence necessitating a high index of suspicion.
Objective: To assess the predictive value of clinico-radiological variables among children presenting with features of suspected FBA and to document their course in a tertiary care teaching hospital.
Materials And Methods: In this retrospective observational study, we included children aged below 15 years presenting with clinical features of suspected FBA.
ERJ Open Res
November 2024
Division of Infection, Immunity and Respiratory Medicine, University of Manchester and Manchester Academic Health Science Centre, Manchester, UK.
Rationale: The measurement of cough frequency is widely used in clinical trials, typically expressed as the number of explosive cough sounds per hour. However, this measure does not capture the clustering of coughs into bouts. Coughing bouts contribute to perceived cough severity and the physical complications of coughing, but an agreed standard definition of cough bouts is lacking.
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