AI Article Synopsis
- The acute retroviral syndrome can lead to various symptoms and lab findings, and this text discusses a rare case of primary HIV infection that caused severe acute hepatitis.* -
- Liver tissue analysis revealed lymphocytic inflammation typical of acute hepatitis and showed high amounts of HIV proviral DNA and p24 antigen in liver cells.* -
- The authors review existing literature on how HIV infects liver cells and the potential consequences for liver health in patients with HIV.*
Article Abstract
The acute retroviral syndrome may present with diverse systemic manifestations and laboratory abnormalities. Here we present a rare case of primary human immunodeficiency virus (HIV) infection causing severe acute hepatitis. Liver histopathology demonstrated a pattern of lymphocytic inflammation consistent with acute hepatitis, high levels of HIV proviral DNA were detected within liver tissue, and immunofluorescence showed HIV p24 antigen within immune and parenchymal cells including hepatocytes. We review the literature pertaining to HIV infection of cell compartments within the liver and discuss the implications for HIV-associated acute liver disease.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10996125 | PMC |
| http://dx.doi.org/10.1093/ofid/ofae170 | DOI Listing |
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