AI Article Synopsis
- Maternal infections during pregnancy can lead to autism spectrum disorder (ASD) in children due to inflammation from maternal immune activation (MIA).
- A study explored traditional Chinese medicine (MFH) to find herbs that might help treat ASD, identifying resveratrol as a key ingredient and Thoc5 as a crucial drug target.
- Experiments showed that resveratrol not only boosted Thoc5 levels but also reduced inflammation in brain cells and improved behaviors related to ASD in offspring of pregnant mice.
Article Abstract
Maternal infection during pregnancy is an important cause of autism spectrum disorder (ASD) in offspring, and inflammatory infiltration caused by maternal immune activation (MIA) can cause neurodevelopmental disorders in the fetus. Medicine food homologous (MFH) refers to a traditional Chinese medicine (TCM) concept, which effectively combines food functions and medicinal effects. However, no previous study has screened, predicted, and validated the potential targets of MFH herbs for treating ASD. Therefore, in this study, we used comprehensive bioinformatics methods to screen and analyze MFH herbs and drug targets on a large scale, and identified resveratrol and Thoc5 as the best small molecular ingredient and drug target, respectively, for the treatment of MIA-induced ASD. Additionally, the results of in vitro experiments revealed that resveratrol increased the expression of Thoc5 and effectively inhibited lipopolysaccharide-induced inflammatory factor production by BV2 cells. Moreover, in vivo, resveratrol increased the expression of Thoc5 and effectively inhibited placental and fetal brain inflammation in MIA pregnancy mice, and improved ASD-like behaviors in offspring.
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| http://dx.doi.org/10.1016/j.jnutbio.2024.109638 | DOI Listing |
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