Exercise induced performance fatigue has been shown to impair many aspects of fine motor function in the distal upper limb. However, most fatiguing protocols do not reflect the conditions experienced with computer use. The purpose of this study was to determine how a prolonged, low-force mouse clicking fatigue protocol impacts performance fatigue of the distal upper limb for gamers and non-gamers. Participants completed a total of 1 h of mouse clicking at 5 clicks per second. Muscle fatigue and performance were intermittently assessed. RMS amplitude increased for the forearm flexors throughout the fatigue protocol. Accuracy decreased following the first bout of clicking and returned to baseline values after 40-min. EDC and ECU displayed the greatest muscle activity while aiming, producing 11.4% and 12.9% of MVC, respectively. These findings indicate that mouse clicking may not result in performance fatigue, however, high levels of extensor activity may explain common injuries among gamers.
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http://dx.doi.org/10.1016/j.apergo.2024.104284 | DOI Listing |
Molecules
January 2025
Department of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark.
The overexpression of the epidermal growth factor receptor (EGFR) in certain types of prostate cancers and glioblastoma makes it a promising target for targeted radioligand therapy. In this context, pairing an EGFR-targeting peptide with the emerging theranostic pair comprising the Auger electron emitter cobalt-58m (Co) and the Positron Emission Tomography-isotope cobalt-55 (Co) would be of great interest for creating novel radiopharmaceuticals for prostate cancer and glioblastoma theranostics. In this study, GE11 (YHWYGYTPQNVI) was investigated for its EGFR-targeting potential when conjugated using click chemistry to N1-((triazol-4-yl)methyl)-N1,N2,N2-tris(pyridin-2-ylmethyl)ethane-1,2-diamine (TZTPEN).
View Article and Find Full Text PDFSci Data
January 2025
Department of Psychology, Faculty of Arts, Masaryk University, Brno, Czech Republic.
Empirical data on human evacuation behavior are invaluable for adjusting and training computational algorithms that simulate evacuation processes, including agent-based modeling. We provide a dataset on human decision-making during evacuations from virtual buildings, captured using experimental methods that controlled specific building layout parameters. An online experiment assigned participants a random subset of tasks featuring T-intersections.
View Article and Find Full Text PDFPLoS One
January 2025
Department of Psychology, Crean College of Health and Behavioral Sciences, Chapman University, Orange, California, United States of America.
Background: Mobile sensing technology allows automated behavior shaping routines to be incorporated into health behavior interventions and other settings. In previous work, a computational model was built to investigate how to best arrange automatic behavior shaping procedures, but the degree to which this model reflects actual human behavior is not known.
Purpose: To translate a previously developed computational model of automatic behavior shaping into an experimental setting.
J Exp Psychol Anim Learn Cogn
January 2025
Universidad del Pais Vasco/Euskal Herriko Unibertsitatea, Procesos Basicos y Su Desarrollo.
Extinction may alter the representation of a cue (e.g., it becomes less salient).
View Article and Find Full Text PDFBiol Res
January 2025
School of Pharmacy, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Background: Protein palmitoylation, a critical posttranslational modification, plays an indispensable role in various cellular processes, including the regulation of protein stability, mediation of membrane fusion, facilitation of intracellular protein trafficking, and participation in cellular signaling pathways. It is also implicated in the pathogenesis of diseases, such as cancer, neurological disorders, inflammation, metabolic disorders, infections, and neurodegenerative diseases. However, its regulatory effects on sperm physiology, particularly motility, remain unclear.
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