A 2021 in silico study highlighted an association between the CD14 polymorphism rs2569190 and increased susceptibility to SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19). The aim of our study was to confirm this finding. We analysed the CD14 polymorphism (C→T; rs2569190) in 516 individuals who tested positive for SARS-CoV-2, with differing disease severity (164 asymptomatic, 245 symptomatic, and 107 hospitalized). We then compared these patients with a sample from the general population consisting of 3,037 individuals using a case-control study design. In comparison with carriers of the C allele, TT homozygotes accounted for 21.7 % of controls and 20.5 % in SARS-CoV-2-positive individuals (P = 0.48; OR; 95 % CI - 0.92; 0.73-1.16). No significant differences in the distribution of genotypes were found when considering co-dominant and recessive genetic models or various between-group comparisons. The CD14 polymorphism is unlikely to be an important predictor of COVID-19 in the Caucasian population in Central Europe.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.14712/fb2023069050181 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Investigating the causal relationship between immune factors and ankylosing spondylitis: insights from a Mendelian Randomization study.
Adv Rheumatol
December 2024
Tianjin Hospital, Tianjin University, No. 406 Jiefang South Rd, Hexi District, Tianjin, 300211, China.
Background: Despite previous studies indicating a close relationship between immune system and ankylosing spondylitis (AS), the causal relationship between them remains unclear.
Methods: Genome-wide association data were utilized to explore the causal link between 731 immune cells and AS using a bidirectional two-sample MR approach. The data included immune cell data from Orrù et al.
Gene prediction of the causal relationship between immune cells and IgA nephropathy: A bidirectional Mendelian randomization study.
Medicine (Baltimore)
November 2024
Division of Planned Immunization, Yiwu Center for Disease Control and Prevention, Yiwu, China.
Article Synopsis
- * This study uses Mendelian randomization to examine the causal links between 731 immune cell types and IgA nephropathy, utilizing data from genome-wide association studies and the FinnGen dataset.
- * Findings indicate that certain immune cells, like CD8 T cells and CD64 monocytes, are linked to increased or decreased risks of IgA nephropathy, suggesting potential pathways for early prevention and tailored treatments.
Genetic association of missense (rs2919643), intergenic (rs2057178) and a 3'UTR (rs1009170) variant with tuberculosis: A replication study from India.
Infect Genet Evol
December 2024
BRIC-National Institute of Biomedical Genomics (NIBMG), Kalyani, West Bengal 741251, India. Electronic address:
Article Synopsis
- - We conducted a study to examine genetic factors influencing tuberculosis susceptibility by analyzing nine specific single nucleotide polymorphisms (SNPs) in a group of TB patients and their household contacts in West Bengal, India.
- - The study found strong associations between TB and three SNPs: rs2919643 (a risk allele), rs2057178 (protective), and rs1009170, confirming their relevance through our research.
- - These SNPs are linked to functions in immune responses and gene regulation in lung cells, suggesting they play a significant role in TB development and susceptibility.
Impact of immune cells on the risk of frozen shoulder: A 2-sample Mendelian randomization study.
Medicine (Baltimore)
November 2024
Department of Bone Surgery, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong Province, China.
The pathogenesis of frozen shoulder (FS) remains unclear, and current research primarily focuses on immune responses. Increasing evidence suggests that immune cells play a significant role in FS development. However, the causal relationship between the two remains poorly understood.
View Article and Find Full Text PDFGenomes and epigenomes of matched normal and tumor breast tissue reveal diverse evolutionary trajectories and tumor-host interactions.
Am J Hum Genet
December 2024
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, USA. Electronic address:
Article Synopsis
- Normal tissues adjacent to breast tumors (NATs) may contain early signs of breast cancer development due to a phenomenon called field cancerization.
- A study using advanced genomic techniques on samples from 43 breast cancer patients in Hong Kong revealed that NATs often had single-nucleotide variants (SNVs) in driver genes also found in tumor samples, but rarely had large-scale genomic changes.
- The researchers identified different evolutionary patterns among NAT and tumor pairs, indicating distinct genomic characteristics and the influence of the tumor microenvironment on cancer development.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!