AI Article Synopsis
- Creatine supplementation may benefit cognition, especially for certain groups like vegans, vegetarians, the elderly, and those who are sleep-deprived or hypoxic, but past reviews have offered limited support.
- A systematic review found that while creatine can increase brain levels, its effects on cognitive performance remain unclear.
- There is a need for more research, particularly focusing on stressed populations and improving study designs, including measuring brain creatine content.
Article Abstract
Creatine supplementation has been put forward as a possible aid to cognition, particularly for vegans, vegetarians, the elderly, sleep deprived and hypoxic individuals. However, previous narrative reviews have only provided limited support for these claims. This is despite the fact that research has shown that creatine supplementation can induce increased brain concentrations of creatine, albeit to a limited extent. We carried out a systematic review to examine the current state of affairs. The review supported claims that creatine supplementation can increases brain creatine content but also demonstrated somewhat equivocal results for effects on cognition. It does, however, provide evidence to suggest that more research is required with stressed populations, as supplementation does appear to significantly affect brain content. Issues with research design, especially supplementation regimens, need to be addressed. Future research must include measurements of creatine brain content.
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| http://dx.doi.org/10.1016/j.bbr.2024.114982 | DOI Listing |
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