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The Usefulness of Exosomes in Accelerating Healing and Preventing Complications in Behçet's Disease: A Case Report.
Cureus
November 2024
Gynecology, CosmeSurge Group, Dubai, ARE.
Behçet's disease (BD) is a systemic auto-inflammatory vasculitis. The clinical pictures of BD involve the skin and mucosal membranes such as oral and genital ulcers, ocular lesions, cardiovascular, gastrointestinal, muscular, nervous systems, and joints. A 38-year-old woman was repeatedly suffering from oral, genital, and ocular lesions, wound dehiscence after any surgical procedure, and joint pain.
View Article and Find Full Text PDFPreparation and Characterization of Silymarin Gel: A Novel Topical Mucoadhesive Formulation for Potential Applicability in Oral Pathologies.
Gels
February 2023
Herb and Food Division, Isha Arogya, Coimbatore 641010, India.
has been used for centuries by herbalists and physicians to treat different forms of liver diseases. It contains flavonoid, which has antioxidant, anti-inflammatory, antifibrotic and anticancer properties. The objective of this research was to develop a silymarin-based mucoadhesive gel for prolonged release in oral mucosa and to evaluate the same by using drug release kinetic models and methods for drug permeation using chicken buccal mucosa.
View Article and Find Full Text PDFGingival Overgrowths Revealing Hamartoma Tumor Syndrome: Report of Novel Pathogenic Variants.
Biomedicines
December 2022
Oral Medicine and Oral Oncology Unit, Department of Oncology, University of Turin, San Luigi Gonzaga Hospital, 10043 Orbassano, Italy.
PTEN hamartoma tumor syndrome (PHTS), is a spectrum of disorders caused by mutations of PTEN, in which non-cancerous growths, called hamartomas, develop in different areas of the body, often including the oral mucosa. PHTS also implies a recognized increased risk of malignancies, as PTEN is a tumor suppressor gene capable of inhibiting progression of several cancers. One of the main and most common clinical manifestation of PHTS are gingival overgrowths presenting as warty lumps.
View Article and Find Full Text PDFAn unusual pigmented tonsil neoplasm presenting to Head & Neck Clinic: a case report and literature review of primary tonsillar malignant mucosal melanoma.
J Surg Case Rep
February 2022
Department of Otolaryngology - Head and Neck Surgery, John Radcliffe Hospital, Headington, Oxford, UK.
Article Synopsis
- Primary mucosal melanoma of the tonsil is rare, with only 27 reported cases, making accurate diagnosis crucial, as it’s often confused with metastatic melanoma.
- A case study highlights a 31-year-old man with primary right tonsillar mucosal melanoma, who presented with neck lumps and was diagnosed after finding a pigmented lesion.
- Due to the aggressive nature of this cancer and generally late diagnosis, treatment options are limited, focusing on local excision for early-stage disease and immunotherapy for advanced cases, leading to a poor prognosis.
Bloody nipple discharge in Carney complex: A case report.
Breast J
December 2021
University of Western Australia, Perth, Western Australia, Australia.
Carney complex (CNC) is an extremely rare, autosomal dominant genetic syndrome consisting of pigmented skin and mucosal changes with multiple endocrine and nonendocrine tumors, including the breast. Breast tumors are typically multiple and benign and are most commonly reported as myxoid fibroadenomas and/or intraductal papillomas. We present a young female patient with known CNC who presented with copious bloody nipple discharge with multiple breast lumps and discuss the breast imaging features regarding this complex and often underrecognized genetic condition.
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