AI Article Synopsis
- New complexes of 2-(N,N-dimethylamino)pyridine (2-DMAP) and 4-(N,N-dimethylamino)pyridine (4-DMAP) were synthesized with chloranilic acid (CLA) and characterized using various methods including X-ray diffraction and NMR spectroscopy.
- Both complexes demonstrated proton transfer, leading to strong hydrogen bonds, and were found to have different crystallization structures.
- Thermal analysis indicated that the methyl groups in 4-DMAP + CLA exhibit faster motion at room temperature compared to the slower motion of CH groups in 2-DMAP + CLA due to steric effects.
Article Abstract
New complexes of 2-(N,N-dimethylamino)pyridine with chloranilic acid (2-DMAP + CLA) and 4-(N,N-dimethylamino)pyridine with chloranilic acid (4-DMAP + CLA) were synthesized and characterized by single crystal X-ray diffraction, infrared spectroscopy, thermal analysis methods and H, C and N NMR spectroscopy. The NMR spectroscopies were carried out in both, DMSO solution and in the solid state (CPMAS NMR). The 2-DMAP + CLA and 4-DMAP + CLA complexes crystallize in centrosymmetric P-1 and P2/c space group, respectively. In both complexes, the phenomenon of proton transfer is observed, which results in the formation of strong N-H···O hydrogen bonds. Thermal decompositions of 2-DMAP + CLA and 4-DMAP + CLA complexes were studied by thermogravimetric analysis. Temperature dependent IR spectra revealed that methyl groups of 4-DMAP + CLA perform fast stochastic reorientational motion at room temperature which is slowed on cooling while in 2-DMAP + CLA reonrientational motion of CH groups is much slower due to steric effects.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.saa.2024.124241 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Green and High Throughput Assay Using 96-Microwell Base to Determine Metformin Hydrochloride in the Tablet Dosage Form.
Int J Anal Chem
August 2024
Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.
Article Synopsis
- Metformin (MET) is a primary treatment for type 2 diabetes, and the study focuses on improving quality control methods for its analysis in pharmaceutical formulations.
- The researchers developed and validated a 96-microwell plate spectrophotometer method using charge-transfer complexes with chloranilic acid and DDQ, demonstrating high precision and accuracy for quantifying MET.
- The new method is efficient, cost-effective, and environmentally friendly, making it a superior alternative for routine MET analysis in quality control laboratories compared to traditional methods.
Electrochemical water oxidation reaction by dinuclear Re(V) oxo complexes with a 1,4-benzoquinone core the redox induced electron transfer (RIET) process.
Dalton Trans
May 2024
Inorganic Chemistry Section, Department of Chemistry, Jadavpur University, Kolkata, 700032, India.
We report two dinuclear rhenium(V) oxo complexes 1 and 2 types, [Re(O)(Cl)(L)Re(O)(Cl)][NBu] (1, L = dianionic 2,5-dihydroxy 1,4-benzoquinone (DBQ)) and (2, L = dianionic chloranilic acid (CA2-) ligands), as a homogeneous electrocatalyst for water oxidation reactions in the acetonitrile-water mixture. The evolution of dioxygen gas at the anode was confirmed by a GC-TCD study. In controlled potential electrolysis (CPE), oxidation at 1.
View Article and Find Full Text PDFInvestigation of hydrogen bonds in proton transfer complexes derived from the reaction of 2- and 4-(N,N-dimethylamino)pyridines with chloranilic acid.
Spectrochim Acta A Mol Biomol Spectrosc
July 2024
Institute of Organic Chemistry Polish Academy of Sciences, Kasprzaka 44, 01-224 Warsaw, Poland.
Article Synopsis
- New complexes of 2-(N,N-dimethylamino)pyridine (2-DMAP) and 4-(N,N-dimethylamino)pyridine (4-DMAP) were synthesized with chloranilic acid (CLA) and characterized using various methods including X-ray diffraction and NMR spectroscopy.
- Both complexes demonstrated proton transfer, leading to strong hydrogen bonds, and were found to have different crystallization structures.
- Thermal analysis indicated that the methyl groups in 4-DMAP + CLA exhibit faster motion at room temperature compared to the slower motion of CH groups in 2-DMAP + CLA due to steric effects.
Development of Visible Spectrophotometric Methods for the Determination of Tricyclic Antidepressants Based on Formation of Molecular Complexes with -Benzoquinones.
Int J Mol Sci
November 2023
Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, 1-7 Gh. Polizu St., District 1, 011061 Bucharest, Romania.
Tricyclic antidepressants are commonly employed in the management of major depressive disorders. The present work describes two visible (VIS) spectrophotometric techniques that utilize the formation of charge transfer complexes between four antidepressant compounds, namely, amitriptyline hydrochloride (AMI), imipramine hydrochloride (IMI), clomipramine hydrochloride (CLO), and trimipramine maleate (TRI) acting as electron donors and two -benzoquinones, namely, -chloranilic acid (pCA) and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), serving as electron acceptors. The stoichiometry of the compounds produced exhibited a consistent 1:1 ratio in all instances, as established by Job's method.
View Article and Find Full Text PDFSpectrophotometric Study of Charge-Transfer Complexes of Ruxolitinib with Chloranilic Acid and 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone: An Application to the Development of a Green and High-Throughput Microwell Method for Quantification of Ruxolitinib in Its Pharmaceutical Formulations.
Molecules
November 2023
Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Ruxolitinib (RUX) is a potent drug that has been approved by the Food and Drug Administration for the treatment of myelofibrosis, polycythemia vera, and graft-versus-host disease. This study describes the formation of colored charge-transfer complexes (CTCs) of RUX, an electron donor, with chloranilic acid (CLA) and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), the π-electron acceptors. The CTCs were characterized using UV-visible spectrophotometry.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!