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Unearthing FLVCR1a: tracing the path to a vital cellular transporter. | LitMetric

Unearthing FLVCR1a: tracing the path to a vital cellular transporter.

Cell Mol Life Sci

Molecular Biotechnology Center (MBC) "Guido Tarone", Department of Molecular Biotechnology and Health Sciences, University of Torino, Via Nizza 52, 10126, Turin, Italy.

Published: April 2024

AI Article Synopsis

  • FLVCR1a is a transporter protein in cats, first identified as the receptor for a retrovirus causing anemia in felines.
  • Despite years of research, its exact functions and regulatory mechanisms remain unclear, sparking ongoing debates.
  • The review aims to summarize existing studies on FLVCR1a, highlighting its critical roles in health and the consequences of its dysfunction.

Article Abstract

The Feline Leukemia Virus Subgroup C Receptor 1a (FLVCR1a) is a member of the SLC49 Major Facilitator Superfamily of transporters. Initially recognized as the receptor for the retrovirus responsible of pure red cell aplasia in cats, nearly two decades since its discovery, FLVCR1a remains a puzzling transporter, with ongoing discussions regarding what it transports and how its expression is regulated. Nonetheless, despite this, the substantial body of evidence accumulated over the years has provided insights into several critical processes in which this transporter plays a complex role, and the health implications stemming from its malfunction. The present review intends to offer a comprehensive overview and a critical analysis of the existing literature on FLVCR1a, with the goal of emphasising the vital importance of this transporter for the organism and elucidating the interconnections among the various functions attributed to this transporter.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10998817PMC
http://dx.doi.org/10.1007/s00018-024-05205-3DOI Listing

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