Soluble adenylyl cyclase (sAC) differs from transmembrane adenylyl cyclases (tmAC) in many aspects. In particular, the activity of sAC is not regulated by G-proteins but by the prevailing bicarbonate concentrations inside cells. Therefore, sAC serves as an exquisite intracellular pH sensor, with the capacity to translate pH changes into the regulation of localization and/or activity of cellular proteins involved in pH homeostasis. In this review, we provide an overview of literature describing the regulation of sAC activity by bicarbonate, pinpointing the importance of compartmentalization of intracellular cAMP signaling cascades. In addition, examples of processes involving proton and bicarbonate transport in different cell types, in which sAC plays an important regulatory role, were described in detail.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11006738 | PMC |
| http://dx.doi.org/10.1007/s00424-024-02952-x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
David Garbers' Contributions to Chemotaxis Signaling in Sperm.
Mol Reprod Dev
October 2024
Life & Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany.
This review focuses on the contribution of the late David Garbers to chemotaxis of sperm, in particular from sea urchin. We will describe his discovery of chemotactic peptides and their cognate receptors, his discovery of a sperm-specific, unique Na/H exchanger that represents a chimera between a solute carrier (SLC) and an ion channel. Finally, we will discuss his contributions to the understanding of cAMP signaling in sperm via soluble adenylyl cyclase (sAC) and its control by Ca ions.
View Article and Find Full Text PDFNovel Genes of the Male Reproductive System: Potential Roles in Male Reproduction and as Non-hormonal Male Contraceptive Targets.
Mol Reprod Dev
October 2024
Center for Drug Discovery, Baylor College of Medicine, Houston, Texas, USA.
The development of novel non-hormonal male contraceptives represents a pivotal frontier in reproductive health, driven by the need for safe, effective, and reversible contraceptive methods. This comprehensive review explores the genetic underpinnings of male fertility, emphasizing the crucial roles of specific genes and structural variants (SVs) identified through advanced sequencing technologies such as long-read sequencing (LRS). LRS has revolutionized the detection of structural variants and complex genomic regions, offering unprecedented precision and resolution over traditional next-generation sequencing (NGS).
View Article and Find Full Text PDFPyrazolo-Pyrimidinones with Improved Solubility and Selective Inhibition of Adenylyl Cyclase Type 1 Activity for Treatment of Inflammatory Pain.
J Med Chem
October 2024
Borch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States.
Article Synopsis
- Adenylyl cyclase isoform 1 (AC1) is being targeted for new treatments for inflammatory pain, and researchers found a promising group of compounds called pyrazolyl-pyrimidinones that effectively inhibit AC1 but initially had poor solubility in water.
- The study presented a new approach to enhance the solubility of these compounds by modifying their structure, which led to a more effective version with a strong inhibition value and better solubility.
- The improved compound showed good absorption in living systems and was effective in reducing pain in a rat model, supporting the idea that inhibiting AC1 could be a viable option for treating chronic pain.
Functional and pathological roles of adenylyl cyclases in various diseases.
Int J Biol Macromol
November 2024
Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Electronic address:
Adenylyl cyclases (ADCYs) produce the second messengers cAMP, which is crucial for a number of cellular activities. There are ten isoforms in the mammalian ADCY family including nine transmembrane adenylyl cyclases (tmAC) and one soluble adenylyl cyclase (sAC/ADCY10). There have been numerous studies demonstrating the importance of ADCYs in the development of a wide range of diseases, including cardiovascular disease, neurological disease, liver disease, and tumors.
View Article and Find Full Text PDFRole of canonical and non-canonical cAMP sources in CRHR2α-dependent signaling.
PLoS One
October 2024
Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA), CONICET, Partner Institute of the Max Planck Society, Buenos Aires, Argentina.
Hippocampal neurons exhibit activation of both the conventional transmembrane adenylyl cyclases (tmACs) and the non-canonical soluble adenylyl cyclase (sAC) as sources of cyclic AMP (cAMP). These two cAMP sources play crucial roles in mediating signaling pathways downstream of CRHR1 in neuronal and neuroendocrine contexts. In this study, we investigate the involvement of both cAMP sources in the molecular mechanisms triggered by CRHR2α.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!