AI Article Synopsis
- - A bio-guided isolation process led to the discovery of six compounds from the Vietnamese lichen Roccella montagnei, including a new compound named montagneside A, alongside five known compounds.
- - The chemical structures of these compounds were determined using advanced techniques like 1D and 2D NMR analysis and high-resolution mass spectroscopy.
- - Evaluation of the compounds showed that D-erythrin and its derivatives significantly inhibited alpha-glucosidase activity, with the most active derivative being analyzed through molecular docking to understand its inhibitory mechanism.
Article Abstract
A bio-guided isolation was applied to the Vietnamese lichen Roccella montagnei based on alpha-glucosidase inhibition. Six compounds were isolated and structurally elucidated, including a new ortho depside, montagneside A (1), together with five known compounds, sekikaic acid (2), lanost-7-en-3β-ol (3), ethyl orsellinate (4), D-montagnetol (5), and D-erythrin (6). Their chemical structures were identified by extensive 1D and 2D NMR analysis, high-resolution mass spectroscopy, and comparisons with those reported in the literature. D-Erythrin (6), a major component, was selected for further modification using Smiles rearrangement. Three erythritol derivatives 6a-6c were synthesized. Compounds 1-3, 6, and 6a-6c were evaluated for alpha-glucosidase inhibition. Compounds 2 and 6a-6c showed significant alpha-glucosidase inhibition with IC values ranging from 7.9 to 149 μM, respectively. Molecular docking was applied to the most active compound 6a to clarify the inhibitory mechanism.
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| http://dx.doi.org/10.1002/cbdv.202400438 | DOI Listing |
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