AI Article Synopsis

  • Surgical stress can weaken the immune system in patients after surgery, increasing the risk of infections and possibly cancer recurrence; this study examines how dietary changes, specifically arginine-enhanced diets, can improve immune function during and after hepatopancreaticobiliary surgery.
  • The study is a randomized controlled trial with 45 patients, aiming to compare immune function and clinical outcomes between a control group and those receiving immunonutrition, measuring changes in natural killer cell activity one day after surgery.
  • Ethical approval has been obtained for the trial, and results will be shared through various channels including conferences, publications, and the ClinicalTrials.gov database to ensure transparency and accessibility of information.

Article Abstract

Introduction: Surgical stress results in immune dysfunction, predisposing patients to infections in the postoperative period and potentially increasing the risk of cancer recurrence. Perioperative immunonutrition with arginine-enhanced diets has been found to potentially improve short-term and cancer outcomes. This study seeks to measure the impact of perioperative immunomodulation on biomarkers of the immune response and perioperative outcomes following hepatopancreaticobiliary surgery.

Methods And Analysis: This is a 1:1:1 randomised, controlled and blinded superiority trial of 45 patients. Baseline and perioperative variables were collected to evaluate immune function, clinical outcomes and feasibility outcomes. The primary outcome is a reduction in natural killer cell killing as measured on postoperative day 1 compared with baseline between the control and experimental cohorts.

Ethics And Dissemination: This trial has been approved by the research ethics boards at participating sites and Health Canada (parent control number: 223646). Results will be distributed widely through local and international meetings, presentation, publication and ClinicalTrials.gov (identifier: NCT04549662). Any modifications to the protocol will be communicated via publications and ClinicalTrials.gov.

Trial Registration Number: ClinicalTrials.gov identifier: NCT04549662.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11002425PMC
http://dx.doi.org/10.1136/bmjopen-2023-072159DOI Listing

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