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| http://dx.doi.org/10.1136/rmdopen-2023-003869 | DOI Listing |
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IL-37 Isoform A Prevents Collagen-Induced Arthritis in Mice by Modulating the Th17/Treg Balance via IL1R8 Receptors.
Int J Mol Sci
November 2024
Institute of Immunology and Inflammatory Diseases, Shenzhen Peking University-The Hong Kong University of Science and Technology (PKU-HKUST) Medical Center, Peking University Shenzhen Hospital, Shenzhen 518036, China.
Cytokines play a complex and pivotal role in modulating synovitis in rheumatoid arthritis. Interleukin (IL)-37 is known for its extensive anti-inflammatory properties that set it apart from the majority of other IL-1 family members. However, IL-37a, a member of the IL-37 family, lacks research into rheumatoid arthritis.
View Article and Find Full Text PDFHigh Humidity Alters Myeloid-Derived Suppressor Cells in Spleen Tissue: Insights into Rheumatoid Arthritis Progression.
J Inflamm Res
November 2024
Research Institute of Chinese Medical Clinical Foundation and Immunology, School of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou, 310053, People's Republic of China.
Article Synopsis
- Rheumatoid arthritis (RA) is an autoimmune disease that leads to joint inflammation and bone damage, and high humidity conditions may worsen its symptoms, though the reasons are not fully understood.
- In a study using a mouse model, researchers investigated how elevated humidity (80%) affects splenic cell types and arthritis severity compared to normal humidity (50%).
- Results showed that high humidity led to increased arthritis symptoms, elevated levels of inflammatory markers, and changes in immune cells (MDSCs) and oxidative stress indicators, suggesting humidity might play a significant role in aggravating RA progression.
Intermittent fasting reduces inflammation and joint damage in a murine model of rheumatoid arthritis: insights from transcriptomic and metagenomic analyses.
BMC Rheumatol
November 2024
PABIOM Laboratory, Faculty of Medicine and Biomedical Sciences, Autonomous University of Chihuahua, Circuito Universitario Campus II, Chihuahua, CP, 31125, Mexico.
Background: Intermittent fasting (IF) has shown benefits in various pathological conditions. Although its anti-inflammatory potential has been recognized, its effects on the mechanism underlying rheumatoid arthritis (RA) remain insufficiently characterized. This study aimed to investigate the effects of IF in a murine model of RA.
View Article and Find Full Text PDFSmall intestinal derived Prevotella histicola simulates biologic as a therapeutic agent.
Sci Rep
November 2024
Department of Immunology, Mayo Clinic, 200 1st St SW, Rochester, MN, 55905, USA.
A role of gut microbiome in pathogenesis as well as response to treatment is documented in rheumatoid arthritis. Using a novel duodenal derived Prevotella histicola strain MCI 001, we have shown that it suppresses disease progression in a collagen-induced arthritis (CIA), a model for rheumatoid arthritis (RA) using humanized mice expressing HLA-DQ8 gene in the absence of endogenous class II genes. Here we compared efficacy of P.
View Article and Find Full Text PDFDeletion of Card9 eliminates the detrimental facets of mycobacterial adjuvants.
Heliyon
October 2024
Department of Immunology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima-City, Kagoshima, 890-8544, Japan.
Article Synopsis
- Mycobacterial adjuvants can trigger strong immune responses but may also lead to harmful autoimmune conditions.
- Deleting the Card9 gene in mice reduced harmful effects like skin inflammation and certain autoimmune diseases while leaving antibody production and some immune responses intact.
- This research suggests that inhibiting Card9 activation during vaccination could help avoid negative immune responses without compromising the body's ability to fight infections and cancer.
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