AI Article Synopsis
- * Out of 541 suspected cases, 24 showed positive IgM but negative rRT-PCR, primarily seen in vaccinated children and a few adults with unclear vaccination history.
- * Our findings suggest that vaccination status and additional tests, like measles IgG avidity and PCR for other viruses, are essential for accurate diagnosis in such cases.
Article Abstract
We investigated clinically suspected measles cases that had discrepant real-time reverse transcription PCR (rRT-PCR) and measles-specific IgM test results to determine diagnoses. We performed rRT-PCR and measles-specific IgM testing on samples from 541 suspected measles cases. Of the 24 IgM-positive and rRT-PCR--negative cases, 20 were among children who received a measles-containing vaccine within the previous 6 months; most had low IgG relative avidity indexes (RAIs). The other 4 cases were among adults who had an unknown previous measles history, unknown vaccination status, and high RAIs. We detected viral nucleic acid for viruses other than measles in 15 (62.5%) of the 24 cases with discrepant rRT-PCR and IgM test results. Measles vaccination, measles history, and contact history should be considered in suspected measles cases with discrepant rRT-PCR and IgM test results. If in doubt, measles IgG avidity and PCR testing for other febrile exanthematous viruses can help confirm or refute the diagnosis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11060445 | PMC |
| http://dx.doi.org/10.3201/eid3005.231757 | DOI Listing |
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