Intrinsically disordered regions (IDRs): A vague and confusing concept for protein function.

Mol Cell

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

Published: April 2024

The term "intrinsically disordered region" (IDR) in proteins has been used in numerous publications. However, most proteins contain IDRs, the term refers to very different types of structures and functions, and many IDRs become structured upon interaction with other biomolecules. Thus, IDR is an unnecessary, vague, and ultimately confusing concept.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11090402PMC
http://dx.doi.org/10.1016/j.molcel.2024.02.023DOI Listing

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