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Dosing optimisation of intravenous lidocaine in patients with class 1-3 obesity by population pharmacokinetic analysis.
Anaesthesia
January 2025
Department of Anaesthesia and Perioperative Medicine, The Royal Brisbane and Women's Hospital, Brisbane, Australia.
Introduction: Evidence to support intra-operative lidocaine infusion regimens in patients with obesity is lacking, risking underdosing or toxicity. We aimed to measure the plasma concentrations of lidocaine and its active metabolites to develop a pharmacokinetic model and optimised dosing regimen in patients with obesity.
Methods: A standardised weight-based intravenous lidocaine regimen was administered to patients with a BMI ≥ 30 kg.
Young-onset dementia: not the same as late-onset dementia - highlighting the differences in diagnosis, care, treatment, and models of care.
Int Psychogeriatr
June 2024
Department of Primary and Community Care, Radboud University Medical Center, Nijmegen, The Netherlands.
Assessing chest radiographic quality and the influence of COVID-19 pathology: the Australian experience.
J Med Radiat Sci
January 2025
Discipline of Medical Imaging Sciences, Faculty of Medicine and Health, University of Sydney, Camperdown, New South Wales, Australia.
Introduction: Quality assurance (QA) in medical imaging ensures consistently high-quality images at acceptable radiation doses. However, the applicability of the chest X-ray (CXR) QA tool in images with pathology, particularly infectious diseases like COVID-19, has not been explored. This study examines the utility of the European Guidelines for image quality in QA of CXRs with varying severity and types of infectious disease.
View Article and Find Full Text PDFAssociation Between COVID-19 Pandemic Phases and the Risk of Maternal Intensive Care Unit Admission: A Retrospective Analysis of 215,363 Victorian Hospital Admissions.
Aust N Z J Obstet Gynaecol
January 2025
Department of Obstetrics, Gynaecology and Newborn Health, Melbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia.
Background: There are no published Australian population-based data on serious COVID-19-associated maternal morbidity before and after widespread vaccination.
Aims: To compare COVID-19 infection rates, intensive care unit (ICU) admissions, and length of stay in hospitalised pregnant patients before and after achieving 70% state-wide maternal COVID-19 vaccination coverage.
Material And Methods: Population-based retrospective cohort study involving all hospital-admitted episodes for pregnant patients over 15-years-old with COVID-19 in Victoria from 1 March 2020 to 31 March 2022.
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