-Fluorosulfonyl Guanidine: An Entry to -Guanyl Sulfamides and Sulfamates.

Here, we present the straightforward synthesis of -fluorosulfonyl guanidine () from two industrial feedstocks, guanidine hydrochloride and sulfuryl fluoride (SOF), using SuFEx chemistry. Compound exhibits excellent stability under ambient conditions and displays unique SuFEx reactivity toward amines and phenols to generate -guanyl sulfamides and sulfamates that have rarely been accessed. Notably, water serves as an effective solvent in this process. Our protocol provides a reliable pathway for the synthesis and investigation of these novel guanidine-containing molecules.