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Sotagliflozin: Efficacy, Safety, and Potential Therapeutic Applications in Heart Failure.

Ann Pharmacother

September 2024

Department of Pharmacy Practice, School of Pharmacy, University of Connecticut, Storrs, CT, USA.

Article Synopsis
  • Sotagliflozin Overview
  • : Sotagliflozin is the first drug approved that inhibits both sodium-glucose cotransporter 1 (SGLT1) and SGLT2, primarily aimed at managing heart failure (HF) in patients with type 2 diabetes mellitus (T2DM).
  • Clinical Evidence
  • : Phase 3 trials (SOLOIST-WHF and SCORED) showed that sotagliflozin significantly reduced cardiovascular and heart failure events compared to a placebo, indicating its potential efficacy in high-risk patients.
  • Patient Care Implications
  • : Despite its approval, established SGLT2 inhibitors like dapagliflozin and empagliflozin have
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