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Ocular biometric parameters in Chinese preschool children and physiological axial length growth prediction using machine learning algorithms: a retrospective cross-sectional study.
BMJ Open
December 2024
Department of Ophthalmology & Clinical Centre of Optometry, Peking University People's Hospital, Beijing, China.
Objectives: To examine the ocular biometric parameters and predict the annual growth rate of the physiological axial length (AL) in Chinese preschool children aged 4-6 years old.
Methods: This retrospective cross-sectional study included 1090 kindergarten students (1090 right eyes) between the ages of 4 and 6 years from Pinggu and Chaoyang District, Beijing. Dioptre values were ascertained following cycloplegic autorefraction.
Choroid vascular index in myopic patients - A mini review.
Taiwan J Ophthalmol
November 2024
Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan.
Myopia has become a globally prevalent ocular disease. The choroid plays a vital role in myopia, and its changes tend to occur earlier than those of the retina and long-term variations in eye growth. Abnormal axial growth is an intrinsic characteristic of myopia, accompanied by ocular biomechanical changes that result in chorioretinal atrophy, thinning, and other complications particularly in the choroidal vasculature.
View Article and Find Full Text PDFThe evaluation of targeted exome sequencing of candidate genes in a Han Chinese population with primary open-angle glaucoma.
Hum Mol Genet
January 2025
Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 83 Fenyang Road, Xuhui District, Shanghai 200031, China.
Primary open-angle glaucoma (POAG), known as a common ocular disease with genetic heterogeneity, is characterized by progressive optic disc atrophy and visual field defects. This study aimed to assess the contribution of previously reported POAG-associated genes and investigate potential functional variations and genotype-phenotype correlations in a Han Chinese population. DNA from 500 cases and 500 controls was pooled and sequenced using a customized panel of 398 candidate genes.
View Article and Find Full Text PDFMyopia in Children: Epidemiology, Genetics, and Emerging Therapies for Treatment and Prevention.
Children (Basel)
November 2024
Department of Ophthalmology, University Hospital of Udine, 33100 Udine, Italy.
Refractive errors, particularly myopia, are among the most prevalent visual impairments globally, with rising incidence in children and adolescents. This review explores the epidemiology and risk factors associated with the development of refractive errors, focusing on the environmental and lifestyle factors contributing to the current surge in myopia. We provide an overview of key genetic factors and molecular pathways driving the pathogenesis of myopia and other refractive errors, emphasizing the complex interplay between genetic predisposition and environmental triggers.
View Article and Find Full Text PDFAssessing Educational Impact of Worldwide Webinar on Management of Myopia Progression in Children.
Int J Environ Res Public Health
December 2024
Division of Pediatric Ophthalmology and Strabismus, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA 15224, USA.
Objective: To assess the educational impact of a worldwide webinar approach to myopia progression management in children <8 years and 8-12 years old.
Design: Cross-sectional study.
Methods: A self-administered survey was conducted for attendees of a 3 h worldwide webinar held in two parts on consecutive days on the management of myopia progression in children.
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