Herein, we report a copper(I)-free method for labeling the trifluoroacetyl group with positron-emitting carbon-11 ( = 20.4 min) or fluorine-18 ( = 109.8 min) as part of our exploration of radiolabeled fluoroforms to access new radiolabeled chemotypes of interest for tracer development. Treatment of alkyl esters and aryl esters, containing electron-donating or electron-withdrawing groups, with [C/F]fluoroform in the presence of strong base, gave [C/F]trifluoromethyl ketones as novel radiolabeling synthons in moderate to high yields within 15 minutes.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11047764 | PMC |
http://dx.doi.org/10.1039/d4cc00465e | DOI Listing |
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