AI Article Synopsis
- The MHC-I system is crucial for immune responses, as it helps present antigens to T cells, and technologies based on it are being used for COVID-19 T cell studies and cancer immunotherapies.
- The diversity of MHC-I alleles is important for personalized medicine but also creates challenges and potential healthcare disparities, particularly affecting underrepresented groups.
- Analysis of recent studies revealed a lack of representation of MHC-I alleles in populations of Asian, Australian, and African descent, highlighting the need for diverse representation in clinical trials to improve global healthcare equality.
Article Abstract
The Major Histocompatibility Complex class I (MHC-I) system plays a vital role in immune responses by presenting antigens to T cells. Allele specific technologies, including recombinant MHC-I technologies, have been extensively used in T cell analyses for COVID-19 patients and are currently used in the development of immunotherapies for cancer. However, the immense diversity of MHC-I alleles presents challenges. The genetic diversity serves as the foundation of personalized medicine, yet it also poses a potential risk of exacerbating healthcare disparities based on MHC-I alleles. To assess potential biases, we analysed (pre)clinical publications focusing on COVID-19 studies and T cell receptor (TCR)-based clinical trials. Our findings reveal an underrepresentation of MHC-I alleles associated with Asian, Australian, and African descent. Ensuring diverse representation is vital for advancing personalized medicine and global healthcare equity, transcending genetic diversity. Addressing this disparity is essential to unlock the full potential of T cells for enhancing diagnosis and treatment across all individuals.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10995142 | PMC |
| http://dx.doi.org/10.1038/s41598-024-58777-2 | DOI Listing |
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