Three new sorbicillinoids sorbicatechols E-G (1-3), along with seven known compounds 4-10, were obtained from the ethanol extract of Penicillium sp. HS-11, a fungal endophyte of the medicinal plant Huperzia serrata. The structures of 1-3 were established by detailed interpretation of the spectroscopic data and their absolute configurations were established by comparative analyses of the ECD spectra. Sorbicatechol G (3) represented the first hybrid sorbicillinoid bearing a tetralone skeleton. In the in-vitro bioassay, trichodimerol (5) exhibited moderate inhibitory activity against the Escherichia coli β-glucuronidase (EcGUS) with an IC value of 92.0 ± 9.4 μM.
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Secondary metabolites from Penicillium sp. HS-11, a fungal endophyte of Huperzia serrata.
Fitoterapia
June 2024
College of Pharmaceutical Science, Zhejiang University of Technology, Hanzhou 310014, PR China. Electronic address:
Three new sorbicillinoids sorbicatechols E-G (1-3), along with seven known compounds 4-10, were obtained from the ethanol extract of Penicillium sp. HS-11, a fungal endophyte of the medicinal plant Huperzia serrata. The structures of 1-3 were established by detailed interpretation of the spectroscopic data and their absolute configurations were established by comparative analyses of the ECD spectra.
View Article and Find Full Text PDFInduced production of a new polyketide in sp. HS-11 by chemical epigenetic manipulation.
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Department of Quality Management, Hangzhou Zhongmeihuadong China Pharmaceutical Co., Ltd, Hangzhou, P. R. China.
Chemical investigation into the culture broth of the plant endophyte sp. HS-11 in the modified Martin's medium supplemented with subemylanilide hydroxamic acid (SAHA), a well-known histone deacetylase (HDACs) inhibitor, led to the isolation and identification of two induced products 4-epipenicillone B () and ()-(+)-chrysogine (). 4-epipenicillone B () was obtained as a new compound whose structure was elucidated by comprehensive spectroscopic methods including 1 D/2D NMR, HRESMS, and quantum chemistry calculations including DFT GIAO C NMR and ECD calculation.
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