Alterations in gamma frequency oscillations correlate with cortical tau deposition in Alzheimer's disease.

Neurobiol Aging

Geneva Memory Center, Division of Geriatrics, Department of Rehabilitation and Geriatrics, Geneva University Hospitals, Geneva, Switzerland; Laboratory of Neuroimaging of Aging (LANVIE), University of Geneva, Geneva, Switzerland.

Published: July 2024

We assessed the relationship of gamma oscillations with tau deposition in Alzheimer's disease (AD) and other cognitive diseases, as both are altered during the disease course and relate to neurodegeneration. We retrospectively analyzed data from 7 AD, tau positive patients and 9 tau negative patients, who underwent cerebral amyloid PET and tau PET, and EEG within 12 months. Relative gamma power was higher in tau positive (AD) patients than in tau negative patients (p < .05). In tau positive AD patients, tau burden was associated with a linear increase in gamma power (p < .05), while no association was present in the tau negative group nor with amyloid-β burden in either group. Thus, increase in the gamma power might represent a novel biomarker for tau driven neurodegeneration.

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Source
http://dx.doi.org/10.1016/j.neurobiolaging.2024.03.008DOI Listing

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