Maternal nutrient metabolism in the liver during pregnancy.

Front Endocrinol (Lausanne)

School of Life Sciences and Food Engineering, Hebei University of Engineering, Handan, China.

Published: April 2024

AI Article Synopsis

  • The liver is crucial for nutrient metabolism in pregnant women, overseeing processes like glucose, lipid, and protein metabolism.
  • The review discusses how the liver adapts to the nutritional needs during pregnancy and what recent findings have emerged about these adaptations.
  • Various hormones and factors, such as estrogen and insulin-like growth factor 1, play significant roles in regulating liver nutrient metabolism during pregnancy, emphasizing the need for more focus on this area to enhance nutrient use and prevent liver diseases.

Article Abstract

The liver plays pivotal roles in nutrient metabolism, and correct hepatic adaptations are required in maternal nutrient metabolism during pregnancy. In this review, hepatic nutrient metabolism, including glucose metabolism, lipid and cholesterol metabolism, and protein and amino acid metabolism, is first addressed. In addition, recent progress on maternal hepatic adaptations in nutrient metabolism during pregnancy is discussed. Finally, the factors that regulate hepatic nutrient metabolism during pregnancy are highlighted, and the factors include follicle-stimulating hormone, estrogen, progesterone, insulin-like growth factor 1, prostaglandins fibroblast growth factor 21, serotonin, growth hormone, adrenocorticotropic hormone, prolactin, thyroid stimulating hormone, melatonin, adrenal hormone, leptin, glucagon-like peptide-1, insulin glucagon and thyroid hormone. Our vision is that more attention should be paid to liver nutrient metabolism during pregnancy, which will be helpful for utilizing nutrient appropriately and efficiently, and avoiding liver diseases during pregnancy.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10987773PMC
http://dx.doi.org/10.3389/fendo.2024.1295677DOI Listing

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