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| http://dx.doi.org/10.3389/fmolb.2024.1386623 | DOI Listing |
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The extracellular matrix component perlecan/HSPG2 regulates radioresistance in prostate cancer cells.
Front Cell Dev Biol
August 2024
Laboratory for Cell Biology and Signalling, Division of Molecular Biology, Ruđer Bošković Institute, Zagreb, Croatia.
Article Synopsis
- Radiotherapy for prostate cancer can lead to radioresistance, which involves cell adhesion signaling and changes in the protein composition of the cell-matrix junctions in cancer cells.
- A mass spectrometry-based analysis compared radioresistant DU145 cells with their parental counterparts, revealing extensive matrix remodeling and altered protein expression, but no change in integrin levels.
- Specific proteins, particularly perlecan/HSPG2, were found to play a crucial role in modulating radioresistance, suggesting that targeting this protein might offer new therapeutic strategies for treating prostate cancer.
Polymerizing laminins in development, health, and disease.
J Biol Chem
July 2024
Department of Biochemistry and Microbiology, Institute for Quantitative Biomedicine, Rutgers University, Piscataway, New Jersey, USA.
Polymerizing laminins are multi-domain basement membrane (BM) glycoproteins that self-assemble into cell-anchored planar lattices to establish the initial BM scaffold. Nidogens, collagen-IV and proteoglycans then bind to the scaffold at different domain loci to create a mature BM. The LN domains of adjacent laminins bind to each other to form a polymer node, while the LG domains attach to cytoskeletal-anchoring integrins and dystroglycan, as well as to sulfatides and heparan sulfates.
View Article and Find Full Text PDFEditorial: Heparan sulfate-binding proteins in health and disease.
Front Mol Biosci
March 2024
Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, United States.
On-demand chlorine dioxide solution enhances odontoblast differentiation through desulfation of cell surface heparan sulfate proteoglycan and subsequent activation of canonical Wnt signaling.
Front Cell Dev Biol
October 2023
Department of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry, Osaka University, Suita, Japan.
Heparan sulfate proteoglycans (HSPGs) surround the surface of odontoblasts, and their modification affects their affinity for Wnt ligands. This study proposes applying Matching Transformation System (MA-T), a novel chlorinated oxidant, to enhance dentinogenesis. MA-T treatment in odontoblasts decreased sulfation of HSPG and upregulated the expression of () and () via activation of canonical Wnt signaling .
View Article and Find Full Text PDFAPOE Christchurch-mimetic therapeutic antibody reduces APOE-mediated toxicity and tau phosphorylation.
Alzheimers Dement
February 2024
Schepens Eye Research Institute of Mass Eye and Ear and Department of Ophthalmology at Harvard Medical School, Boston, Massachusetts, USA.
Introduction: We discovered that the APOE3 Christchurch (APOE3Ch) variant may provide resistance to Alzheimer's disease (AD). This resistance may be due to reduced pathological interactions between ApoE3Ch and heparan sulfate proteoglycans (HSPGs).
Methods: We developed and characterized the binding, structure, and preclinical efficacy of novel antibodies targeting human ApoE-HSPG interactions.
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