Treatment of knee cartilage lesions in 2024: From hyaluronic acid to regenerative medicine.

J Exp Orthop

Cartilage Research Unit, Team Orthopedic Research Region Halland-TOR, Region Halland Orthopaedics, Varberg Hospital University of Gothenburg Varberg Sweden.

Published: April 2024

AI Article Synopsis

  • Intact articular cartilage is crucial for joint health, and effective local repairs are essential to restore joint balance.
  • The main cells involved in cartilage repair are chondrocytes and chondrogenic cells sourced from various tissues like bone and fat.
  • Current trends favor one-stage surgical procedures, making them more appealing due to easier regulatory compliance, and this review covers both nonoperative and surgical repair options for cartilage lesions.

Article Abstract

Abstract: Intact articular cartilage plays a vital role in joint homeostasis. Local cartilage repairs, where defects in the cartilage matrix are filled in and sealed to congruity, are therefore important treatments to restore a joint equilibrium. The base for all cartilage repairs is the cells; either chondrocytes or chondrogeneic cells from bone, synovia and fat tissue. The surgical options include bone marrow stimulation techniques alone or augmented with scaffolds, chondrogeneic cell implantations and osteochondral auto- or allografts. The current trend is to choose one-stage procedures being easier to use from a regulatory point of view. This narrative review provides an overview of the current nonoperative and surgical options available for the repair of various cartilage lesions.

Level Of Evidence: Level IV.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10985633PMC
http://dx.doi.org/10.1002/jeo2.12016DOI Listing

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