Developing a digital twin (DT) involves establishing (1) a predictive capability (a model) relevant to the application, (2) means to collect data from the physical counterpart, and (3) means to apply the collected data to the model. Ideally, with these three goals achieved, long periods of steady-state use of the DT might be interrupted only by failure of the sensors used to collect data from the physical counterpart. In reality, however, it can be difficult to confirm that the DT system occupies this comfortable steady-state position. Assessing uncertainty in the predictive model, and ensuring the relevance of data collected from the physical counterpart are design-time activities with unclear termination points. Distinguishing sensed change in the physical counterpart from sensor failure is a persistent challenge. In this short paper we describe early work towards a human-centered framework to establish, refine, and update digital twins. Condition-based maintenance and gear backlash in production equipment are used as examples.
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http://dx.doi.org/10.1016/j.mfglet.2023.06.002 | DOI Listing |
Alzheimers Dement
December 2024
University of Washington, Seattle, WA, USA.
Background: Loneliness and depression among older adults are linked to a higher likelihood of chronic diseases, deterioration of physical function, and compromised quality of life. LGBTQ older adults are known to experience social isolation and mental distress at higher rates than their heterosexual counterparts, and those with cognitive impairment may be particularly susceptible to loneliness and depression. However, there is limited knowledge regarding the risk and protective factors for loneliness and depression among LGBTQ older adults living with cognitive impairment.
View Article and Find Full Text PDFClin J Pain
January 2025
Department of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital, Boston, MA, USA.
Objectives: Chronic pain (CP) significantly impacts emotional and physical well-being and overall quality of life across diverse populations in the United States (U.S.).
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Michigan, Ann Arbor, MI, USA.
Background: Marital status is an important but often overlooked sociodemographic factor that could shape cognitive health in late adulthood. Being married is shown to be linked to lower risk of dementia, but less is understood about underlying mechanisms contributing to this relationship, such as brain reserve (BR) and cognitive reserve (CR). Further, less is known about how living arrangement, independent of marital status, is associated with late-life cognition.
View Article and Find Full Text PDFDigit Health
January 2025
Faculty IV: School of Science and Technology, Institute for Knowledge-Based Systems and Knowledge Management, University of Siegen, Siegen, Germany.
Objective: Digital twins (DTs) emerged in the wake of Industry 4.0 and the creation of cyber-physical systems, motivated by the increased availability and variability of machine and sensor data. DTs are a concept to create a digital representation of a physical entity and imitate its behavior, while feeding real-world data to the digital counterpart, thus allowing enabling digital simulations related to the real-world entity.
View Article and Find Full Text PDFJ Neurol
January 2025
Department of Neurology and Institute of Neurology, Ruijin Hospital, Affiliated with Shanghai Jiao Tong University School of Medicine, 197 Ruijin Er Road, Shanghai, 200025, China.
Background: Bilateral deep brain stimulation (DBS) of subthalamic nucleus (STN) has demonstrated efficacy for ameliorating medication-refractory isolated dystonia. Nonetheless, the paucity of evidence regarding its long-term impact on quality-of-life (QoL) necessitates further investigation.
Objectives: This study aimed to elucidate the longitudinal effects of chronic STN stimulation on QoL in patients suffering from isolated dystonia.
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