AI Article Synopsis
- Checkpoint blockade immunotherapies have shown that T cells are essential for combating cancer, leading to new strategies that target specific cancer cell antigens.
- The genetic diversity of human leukocyte antigen (HLA) class I alleles among different populations significantly impacts the effectiveness of HLA class I-restricted cancer therapies.
- This diversity is critical for the development of research and diagnostic tools aimed at improving cancer treatment outcomes.
Article Abstract
The success of checkpoint blockade cancer immunotherapies has unequivocally confirmed the critical role of T cells in cancer immunity and boosted the development of immunotherapeutic strategies targeting specific antigens on cancer cells. The vast immunogenetic diversity of human leukocyte antigen (HLA) class I alleles across populations is a key factor influencing the advancement of HLA class I-restricted therapies and related research and diagnostic tools.
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| http://dx.doi.org/10.1158/2159-8290.CD-23-1536 | DOI Listing |
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