Rakicidin J () and rakicidin K (), two new cyclic depsipeptides, were isolated from culture broth of FIM-R150103. Their structures were elucidated by extensive analysis of NMR, HR-ESI-MS, and electronic circular dichroism (ECD) data. The two compounds showed strong cytotoxic activity against human colon carcinoma HCT-8 and human pancreatic cancer PANC-1 cells under normoxic and hypoxic conditions in the range of IC values from 0.024 to 0.79 μg/mL. Moreover, compounds and also showed moderate antibacterial activity against ten Gram-positive bacterial strains with MIC values ranging from 4 to more than 32 μg/mL. Structure-activity relationship of these two compounds with a close analogue, rakicidin B1, is also discussed.
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