Eimeria media is a principal pathogen responsible for rabbit coccidiosis, targeting the rabbit's intestinal epithelial cells. This parasitism damages the intestinal mucosal barrier, initiating a systemic immune and inflammatory response that jeopardizes the sustainable growth of rabbit farming. To understand the implications of infection on the host's immune and metabolic responses, we employed RNA-Seq to analyze RNA from the liver and duodenum tissues of post-infected rabbits infected with both the precocious line and wild-type strain of E.media. Comprehensive transcriptomic analysis revealed that the two parasites exhibit divergent transcriptomic imprints on host tissues. While the precocious line predominantly modulates immune-centric pathways with significant differential gene enrichment, wild-type strain favors pathways that affect metabolism. In addition, our study pinpointed a set of genes that undergo significant modifications in response to these effects. These revelations grant a fresh avenue to probe deeper into the symbiotic intricacies of the E.media and its rabbit host.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00436-024-08186-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Identification and bioinformatics analysis of the DUS gene in Eimeria media.
BMC Vet Res
January 2025
National Key Laboratory of Veterinary Public Health Security, Key Laboratory of Animal Epidemiology and Zoonosis of Ministry of Agriculture, National Animal Protozoa Laboratory & College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China.
This study aims to explore the coding sequence (CDS) of the putative DUS gene in Eimeria media and assess its potential biological functions during the parasite's lifecycle. Initially, oocysts were isolated from fecal samples of rabbits infected with E. media, from which DNA and RNA were extracted.
View Article and Find Full Text PDFKinesin-like motor protein KIF23 maintains neural stem and progenitor cell pools in the developing cortex.
EMBO J
December 2024
Department of Developmental Neuroscience, Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-Ku, Sendai, Miyagi, 980-8577, Japan.
Accurate mitotic division of neural stem and progenitor cells (NSPCs) is crucial for the coordinated generation of progenitors and mature neurons, which determines cortical size and structure. While mutations in the kinesin-like motor protein KIF23 gene have been recently linked to microcephaly in humans, the underlying mechanisms remain elusive. Here, we explore the pivotal role of KIF23 in embryonic cortical development.
View Article and Find Full Text PDFHuman cartilage model of the precocious osteoarthritis-inducing p.Arg719Cys reveals pathology-driving matrix defects and a failure of the ER proteostasis network to recognize the defective procollagen-II.
bioRxiv
November 2024
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA, United States.
Article Synopsis
- Mutations in the procollagen-II gene, like p.Arg719Cys, can lead to chondrodysplasias and associated osteoarthritis, which are difficult to study due to a lack of accurate models.
- Researchers developed human cartilage from both wild-type and Arg719Cys isogenic induced pluripotent stem cell (iPSC) lines to understand the molecular basis of these diseases.
- The findings revealed that Arg719Cys collagen-II was improperly modified and retained in cells, causing defects in collagen matrix deposition without triggering stress responses, suggesting that defective protein folding remains unrecognized by the cells.
Transcriptomic Insights into the Developmental Dynamics of : A Comparative Study of a Precocious Line and the Wild Type.
Genes (Basel)
June 2024
Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China.
Coccidiosis, a parasitic disease caused by single or multiple species, leads to significant economic losses in the poultry industry. The life cycle includes schizogony, gametogony, and sporogony. To investigate the dynamics of gene expression and regulatory networks during the development of , we employed time-course transcriptomics to rigorously compare the gene expression patterns between a precocious line (PL) and the wild type (WT) of .
View Article and Find Full Text PDFLoss of bmp15 function in the seasonal spawner Atlantic salmon results in ovulatory failure.
FASEB J
July 2024
Research Group Reproduction and Developmental Biology, Institute of Marine Research, Bergen, Norway.
Bone morphogenetic protein 15 (BMP15) is an oocyte-specific growth factor important for successful female reproduction in mammals. While mutations in BMP15/Bmp15 cause ovulatory deficiency and/or infertility in certain mammalian species, loss of bmp15 in zebrafish, a continuous spawner and the only bmp15 knockout model in fish to date, results in complete arrest of follicle development and later female-to-male sex reversal, preventing to examine effects on ovulation/fertilization. Here, we used Atlantic salmon, a seasonal spawner, and generated bmp15 mutants to investigate ovarian development and fertility.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!