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Supplements for cognitive ability in patients with mild cognitive impairment or Alzheimer's disease: a protocol for systematic review and network meta-analysis of randomised controlled trials. | LitMetric

AI Article Synopsis

  • The text addresses the rising prevalence of Alzheimer's disease (AD) and mild cognitive impairment (MCI), highlighting the need for effective and safe treatments, particularly through oral supplements.
  • A systematic review will be conducted by analyzing randomized controlled trials from various databases to determine the impact of these supplements on cognitive function in patients with AD or MCI.
  • The study plans to conduct its analysis between June and October 2023, utilizing tools for bias assessment and evidence quality, with results intended for publication or conference presentation.

Article Abstract

Introduction: Considering the increasing incidence of Alzheimer's disease (AD) and mild cognitive impairment (MCI) worldwide, there is an urgent need to identify efficacious, safe and convenient treatments. Numerous investigations have been conducted on the use of supplements in this domain, with oral supplementation emerging as a viable therapeutic approach for AD or MCI. Nevertheless, given the multitude of available supplements, it becomes imperative to identify the optimal treatment regimen.

Methods And Analysis: Eight academic databases and three clinical trial registries will be searched from their inception to 1 June 2023. To identify randomised controlled trials investigating the effects of supplements on patients with AD or MCI, two independent reviewers (X-YZ and Y-QL) will extract relevant information from eligible articles, while the risk of bias in the included studies will be assessed using the Rob 2.0 tool developed by the Cochrane Collaboration. The primary outcome of interest is the overall cognitive function. Pair-wise meta-analysis will be conducted using RevMan V.5.3, while network meta-analysis will be carried out using Stata 17.0 and ADDIS 1.16.8. Heterogeneity test, data synthesis and subgroup analysis will be performed if necessary. The GRADE system will be employed to assess the quality of evidence. This study is scheduled to commence on 1 June 2023 and conclude on 1 October 2023.

Ethics And Dissemination: Ethics approval is not required for systematic review and network meta-analysis. The results will be submitted to a peer-reviewed journal or at a conference.

Trial Registration Number: PROSPERO (CRD42023414700).

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10989123PMC
http://dx.doi.org/10.1136/bmjopen-2023-077623DOI Listing

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