AI Article Synopsis
- Photoacoustic imaging (PAI) combined with ultrasound (US) is a non-invasive method for visualizing and measuring tumor hypoxia in live animals.
- The text details a step-by-step protocol using a breast tumor xenograft model, covering animal preparation, equipment setup, and image acquisition procedures.
- It also includes guidance on data analysis, the functional insights from PAI, and the potential uses of this technology to explore the hypoxic environment of tumors.
Article Abstract
Photoacoustic imaging (PAI) with co-registered ultrasound (US) is a hybrid non-invasive imaging modality that enables visualization and quantification of tumor hypoxia in live animals. Here, using a breast tumor xenograft model as an example, we present a stepwise protocol describing animal preparation, positioning, instrument setup, and US-PAI image acquisition procedures. This protocol also guides through detailed data analysis, explains functional readouts obtained from PAI, and discusses the potential application of the technology to study the hypoxic tumor microenvironment. For complete details on the use and execution of this protocol, please refer to Dai et al..
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10999710 | PMC |
| http://dx.doi.org/10.1016/j.xpro.2024.102993 | DOI Listing |
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