Background: Extra spindle pole bodies-like 1 () is known to play a crucial role in the segregation of sister chromatids during mitosis. Overexpression of is considered to have oncogenic effects in various human cancers. However, the specific biological function of in endometrial cancer (EC) remains unclear.
Methods: The TCGA and GEO databases were utilized to assess the expression of in EC. Immunohistochemistry was utilized to detect separase expression in EC samples. Kaplan-Meier survival analysis and Cox regression analysis were performed to evaluate the diagnostic and prognostic significance of in EC. Gene Set Enrichment Analysis (GSEA) was employed to explore the potential signaling pathway of in EC. Cell proliferation and colony formation ability were analyzed using CCK-8 and colony formation assay.
Results: Our analysis revealed that is significantly upregulated in EC, and its overexpression is associated with advanced clinical characteristics and unfavourable prognostic outcomes. Suppression of attenuated proliferation of EC cell line.
Conclusion: The upregulation of is associated with advanced disease and poor prognosis in EC patients. These findings suggest that has the potential to serve as a diagnostic and prognostic biomarker in EC, highlighting its significance in the management of EC patients.
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