Pseudoindoxyl is a partial skeleton found in various natural products. Its light-absorption properties make it useful for the design of functional molecules. However, versatile synthesis methods have not yet been reported. In this report, we present a versatile synthetic method for pseudoindoxyls using the direct S → T transition under visible light irradiation. We also discuss the application of pseudoindoxyls as photocatalysts.
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http://dx.doi.org/10.1021/acs.orglett.4c00957 | DOI Listing |
Theranostics
January 2025
Department of Internal Medicine III, School of Medicine and Health, Technical University of Munich, Munich, Germany.
Here we report results of a phase 1 multi-institutional, open-label, dose-escalation trial (NCT02744287) of BPX-601, an investigational autologous PSCA-directed GoCAR-T® cell product containing an inducible MyD88/CD40 ON-switch responsive to the activating dimerizer rimiducid, in patients with metastatic pancreatic (mPDAC) or castration-resistant prostate cancer (mCRPC). Primary objectives were to evaluate safety and tolerability and determine the recommended phase 2 dose/schedule (RP2D). Secondary objectives included the assessment of efficacy and characterization of the pharmacokinetics of rimiducid.
View Article and Find Full Text PDFFront Cardiovasc Med
December 2024
Panzhihua Central Hospital, Panzhihua, Sichuan, China.
Background: Abdominal aortic aneurysm (AAA) is a localized bulge of the abdominal aorta, which mainly manifests as a pulsatile mass in the abdomen. Once an abdominal aortic aneurysm ruptures, the patient's life is seriously endangered. Surgery is the preferred treatment for abdominal aortic aneurysm.
View Article and Find Full Text PDFJ Biomech
December 2024
Intelligent Systems for Medicine Laboratory, The University of Western Australia, Perth, Western Australia, Australia.
A search in Scopus within "Article title, Abstract, Keywords" unveils 2,444 documents focused on the biomechanics of Abdominal Aortic Aneurysm (AAA), mostly on AAA wall stress. Only 24 documents investigated AAA kinematics, an important topic that could potentially offer significant insights into the biomechanics of AAA. In this paper, we present an image-based approach for patient-specific, in vivo, and non-invasive AAA kinematic analysis using patient's time-resolved 3D computed tomography angiography (4D-CTA) images, with an objective to measure wall displacement and strain during the cardiac cycle.
View Article and Find Full Text PDFBiochim Biophys Acta Mol Cell Res
December 2024
Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu 226001, China. Electronic address:
Microtubule-severing enzymes such as spastin, katanin, and fidgetin, characterized by their AAA ATPase domains, are pivotal in modulating microtubule dynamics and behavior across various cellular processes. While spastin and katanin are recognized for their predominant and robust severing of stable microtubules, thereby enhancing microtubule turnover, fidgetin exhibits comparatively weaker severing activity and selectively targets labile microtubules. The interplay among these enzymes and their mutual regulatory mechanisms remains inadequately understood.
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