Given the widespread and established use of (Retz) Vahl, a member of the Oleacea family, this study aimed to identify and characterise secondary metabolites derived from the plant, with the objective of evaluating their potential biological activities. Using chromatographic separations techniques based on molecular weight and polarity, various VLC fractions of the plant were purified. These fractions yielded seven compounds- 2-(4-hydroxyphenyl)-ethanol , 2-(4-hydroxy-3-methoxy-phenyl)-ethanol , 1-(4-hydroxy-3-methoxy-phenyl)-1,2,3-propanetriol , 1-(4-hydroxy-3,5-dimethoxy-phenyl)-1,2,3-propanetriol , lupeol , β-sitosterol , and methyl linoleate , which have never been previously reported in this plant. Out of the seven identified compounds, compounds 3 and 4 had the greatest capacity to scavenge free radicals with IC values of 3.81 µg/ml and 4.08 µg/ml, respectively when compared to the standard Butylated Hydroxy Toluene (BHT) with IC value of 6.54 µg/ml.
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Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh.
Given the widespread and established use of (Retz) Vahl, a member of the Oleacea family, this study aimed to identify and characterise secondary metabolites derived from the plant, with the objective of evaluating their potential biological activities. Using chromatographic separations techniques based on molecular weight and polarity, various VLC fractions of the plant were purified. These fractions yielded seven compounds- 2-(4-hydroxyphenyl)-ethanol , 2-(4-hydroxy-3-methoxy-phenyl)-ethanol , 1-(4-hydroxy-3-methoxy-phenyl)-1,2,3-propanetriol , 1-(4-hydroxy-3,5-dimethoxy-phenyl)-1,2,3-propanetriol , lupeol , β-sitosterol , and methyl linoleate , which have never been previously reported in this plant.
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