AI Article Synopsis
- This study looked at a substance called leptin in body fluids to see if it could help diagnose endometriosis, a medical condition that affects women.
- Researchers checked the levels of leptin in samples from women who might have endometriosis and found no big differences in most cases.
- The study suggests that measuring leptin might not be a good way to diagnose endometriosis, and more research is needed to be sure.
Article Abstract
Background: The aim of this study was to analyze the concentration of leptin in peritoneal fluid and plasma and to assess their role as potential biomarkers in the diagnosis of endometriosis.
Materials & Methods: Leptin adjusted for BMI (leptin/BMI ratio) was measured using surface plasmon resonance imaging (SPRI) biosensors. Patients with suspected endometriosis were included in the study. Plasma was collected from 70 cases, and peritoneal fluid from 67 cases. Based on the presence of endometriosis lesions detected during laparoscopy, patients were divided into a study group and a control group (patients without endometriosis).
Results: Leptin/BMI ratio in plasma did not differ between women with endometriosis and the control group (0.7159 ± 0.259 vs 0.6992 ± 0.273, p= 0,7988). No significant differences were observed in peritoneal leptin/BMI ratio levels in patients with and without endometriosis (0.6206 ± 0.258 vs 0.6215 ± 0.264, p= 0,9896). Plasma and peritoneal leptin/BMI ratios were significantly lower in women with endometriosis - related primary infertility compared to women with endometriosis without primary infertility (0.640 ± 0.502 vs 0.878 ± 0.623, p < 0.05). The difference was observed in case of primary infertility, but not in terms of the secondary one. No significant differences were noted between leptin/BMI ratio in the proliferative phase and the secretory phase (0.716 ± 0.252 vs 0.697 ± 0.288, p= 0,7785).
Conclusion: The results of present study do not support the relevance of leptin concentration determination as a biomarker of the endometriosis. Due to the limited number of samples in the tested group, further studies are needed to confirm its role.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10985179 | PMC |
| http://dx.doi.org/10.3389/fendo.2024.1359182 | DOI Listing |
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Article Synopsis
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- Researchers checked the levels of leptin in samples from women who might have endometriosis and found no big differences in most cases.
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