AI Article Synopsis
- The text discusses interleukin 17 (IL-17)-producing CD8 T cells, known as Tc17 cells, highlighting their role in mucosal defense and inflammatory responses in diseases like psoriasis, multiple sclerosis, and inflammatory bowel disease.
- It aims to summarize current understanding of the characteristics, development, and generation of Tc17 cells.
- The review also examines the involvement of Tc17 cells in various human conditions, including infectious diseases, cancer, and immune-related disorders.
Article Abstract
The term refers to interleukin 17 (IL-17)-producing CD8 T cells. While IL-17 is an important mediator of mucosal defense, it is also centrally involved in driving the inflammatory response in immune-mediated diseases, such as psoriasis, multiple sclerosis, and inflammatory bowel disease. In this review, we aim to gather the current knowledge on the phenotypic and transcriptional profile, the and generation of Tc17 cells, and the evidence pointing towards a relevant role of Tc17 cells in human diseases such as infectious diseases, cancer, and immune-mediated diseases.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10917240 | PMC |
| http://dx.doi.org/10.1093/discim/kyad010 | DOI Listing |
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